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P2rx3 Gene Detail
Summary
  • Symbol
    P2rx3
  • Name
    purinergic receptor P2X, ligand-gated ion channel, 3
  • Synonyms
    4930513E20Rik, MGC:28163, P2X3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097160
    NCBI Gene: 228139
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84828927-84867806 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    752 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097160
 protein coding gene Chr2:84826893-84867806 (-)
129S1/SvImJ ENSMUSG00200051306
 protein coding gene Chr2:81845499-81884379 (-)
A/J ENSMUSG00195050461
 protein coding gene Chr2:81958233-81997150 (-)
AKR/J ENSMUSG00220050282
 protein coding gene Chr2:81836972-81875878 (-)
BALB/cJ ENSMUSG00180054630
 protein coding gene Chr2:81886065-81924972 (-)
C3H/HeJ ENSMUSG00175052030
 protein coding gene Chr2:82025635-82064543 (-)
C57BL/6NJ ENSMUSG00215051151
 protein coding gene Chr2:81930611-81969494 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023738
 protein coding gene Chr2:79211442-79251448 (-)
CAST/EiJ ENSTCUG00005052254
 protein coding gene Chr2:81378434-81417305 (-)
CBA/J ENSMUSG00210027447
 protein coding gene Chr2:82053546-82092458 (-)
DBA/2J ENSMUSG00185056674
 protein coding gene Chr2:81882303-81921211 (-)
FVB/NJ ENSMUSG00205047606
 protein coding gene Chr2:81264483-81303350 (-)
JF1/MsJ ENSUMUG00000004541
 protein coding gene Chr2:81799981-81839425 (-)
LP/J ENSMUSG00230041546
 protein coding gene Chr2:83633379-83672285 (-)
NOD/ShiLtJ ENSMUSG00190044402
 protein coding gene Chr2:81922922-81961827 (-)
NZO/HlLtJ ENSMUSG00225001967
 protein coding gene Chr2:91518057-91556962 (-)
PWK/PhJ ENSLUMG00010047996
 protein coding gene Chr2:81816638-81856061 (-)
SPRET/EiJ ENSMSPG00010051468
 protein coding gene Chr2:83719332-83758769 (-)
WSB/EiJ ENSIUOG00005053144
 protein coding gene Chr2:81863530-81902406 (-)



Homology
more
  • Human Ortholog
    P2RX3, purinergic receptor P2X 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RX3, purinergic receptor P2X 3
  • Synonyms
    P2X3
  • Links
    NCBI Gene ID: 5024
    UniProt: P56373

  • Chr Location
    11q12.1; chr11:57335950-57372404 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show normal ventilatory responses to hypoxia. Mice homozygous for a reporter allele show loss of rapidly desensitizing ATP-gated cation currents in dorsal root ganglion neurons, reduced formalin-evoked pain behavior, and enhanced thermal hyperalgesia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    86
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    120
  • cDNA Data
    9
  • Literature Summary
    23
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027071 Ensembl Gene Model | MGI Sequence Detail 38880 C57BL/6J ±  kb
transcript ENSMUST00000028465 Ensembl | MGI Sequence Detail 1812 Not Applicable  
polypeptide ENSMUSP00000028465 Ensembl | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 3
    cDNA 9
    Primer pair 1
    Other 3
    Antibodies 5

    Microarray probesets 4
Other
Accession IDs
less
MGI:1926054
References
more
  • Summaries
    All 108
    Developmental Gene Expression 23
    Gene Ontology 21
    Phenotypes 35
  • Earliest
    J:42467 Souslova V, et al., Structure and chromosomal mapping of the mouse P2X3 gene. Gene. 1997 Aug 11;195(1):101-11
  • Latest
    J:385781 Tang T, et al., Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons. J Neurosci. 2026 Apr 8;46(14)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory