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Utp4 Gene Detail
Summary
  • Symbol
    Utp4
  • Name
    UTP4 small subunit processome component
  • Synonyms
    Cirh1a, TEG-292, Tex292
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096573
    NCBI Gene: 21771
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:107620268-107649720 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    720 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096573
 protein coding gene Chr8:107620268-107649726 (+)
129S1/SvImJ ENSMUSG00200012941
 protein coding gene Chr8:101895794-101925339 (+)
A/J ENSMUSG00195017477
 protein coding gene Chr8:102218422-102247959 (+)
AKR/J ENSMUSG00220014132
 protein coding gene Chr8:102357417-102386957 (+)
BALB/cJ ENSMUSG00180024218
 protein coding gene Chr8:102224176-102253718 (+)
C3H/HeJ ENSMUSG00175022060
 protein coding gene Chr8:102281228-102310769 (+)
C57BL/6NJ ENSMUSG00215025776
 protein coding gene Chr8:101899813-101929270 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031525
 protein coding gene Chr8:98020898-98050848 (+)
CAST/EiJ ENSTCUG00005031279
 protein coding gene Chr8:101658967-101687196 (+)
CBA/J ENSMUSG00210031811
 protein coding gene Chr8:102208558-102238096 (+)
DBA/2J ENSMUSG00185005653
 protein coding gene Chr8:108317279-108346857 (+)
FVB/NJ ENSMUSG00205010561
 protein coding gene Chr8:101197203-101226663 (+)
JF1/MsJ ENSUMUG00000005183
 protein coding gene Chr8:110650473-110680015 (+)
LP/J ENSMUSG00230028677
 protein coding gene Chr8:111997623-112027165 (+)
NOD/ShiLtJ ENSMUSG00190019077
 protein coding gene Chr8:102347872-102377333 (+)
NZO/HlLtJ ENSMUSG00225017479
 protein coding gene Chr8:115348181-115377725 (+)
PWK/PhJ ENSLUMG00010025298
 protein coding gene Chr8:102138226-102166841 (+)
SPRET/EiJ ENSMSPG00010037554
 protein coding gene Chr8:104209632-104237036 (+)
WSB/EiJ ENSIUOG00005027159
 protein coding gene Chr8:103025628-103055079 (+)



Homology
more
  • Human Ortholog
    UTP4, UTP4 small subunit processome component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UTP4, UTP4 small subunit processome component
  • Synonyms
    CIRH1A, CIRHIN, NAIC, TEX292
  • Links
    NCBI Gene ID: 84916
    UniProt: Q969X6

  • Chr Location
    16q22.1; chr16:69131291-69231130 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human UTP4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, morula-like embryos fail to hatch from the zona pellucida and die after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    636
  • Tissues
    7
  • cDNA Data
    88
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041438 Ensembl Gene Model | MGI Sequence Detail 29453 C57BL/6J ±  kb
    transcript ENSMUST00000047629 Ensembl | MGI Sequence Detail 2232 Not Applicable  
    polypeptide ENSMUSP00000048377 Ensembl | MGI Sequence Detail 686 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005500 U3 small nucleolar RNA-associated protein 4 homolog
      (term hierarchy)
    • InterPro Domains
      IPR046351 U3 small nucleolar RNA-associated protein 4
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 88
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:35463 Lopez-Fernandez LA, et al., Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. Mamm Genome. 1996 Sep;7(9):698-700
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory