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Fut2 Gene Detail
Summary
  • Symbol
    Fut2
  • Name
    fucosyltransferase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109374
    NCBI Gene: 14344
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45298015-45315818 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.41 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    631 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109374
 protein coding gene Chr7:45298015-45315818 (-)
129S1/SvImJ ENSMUSG00200025590
 protein coding gene Chr7:32895727-32919036 (-)
A/J ENSMUSG00195039575
 protein coding gene Chr7:36927927-36946688 (-)
AKR/J ENSMUSG00220008472
 protein coding gene Chr7:31227155-31244956 (-)
BALB/cJ ENSMUSG00180032045
 protein coding gene Chr7:33803322-33822084 (-)
C3H/HeJ ENSMUSG00175026251
 protein coding gene Chr7:34331649-34354956 (-)
C57BL/6NJ ENSMUSG00215037295
 protein coding gene Chr7:33590840-33608645 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029734
 protein coding gene Chr7:47588437-47616863 (-)
CAST/EiJ ENSTCUG00005042603
 protein coding gene Chr7:37333914-37352536 (-)
CBA/J ENSMUSG00210047607
 protein coding gene Chr7:34701838-34719643 (-)
DBA/2J ENSMUSG00185036503
 protein coding gene Chr7:38578467-38601774 (-)
FVB/NJ ENSMUSG00205043020
 protein coding gene Chr7:34246383-34264190 (-)
JF1/MsJ ENSUMUG00000039520
 protein coding gene Chr7:43058176-43081483 (-)
LP/J ENSMUSG00230050687
 protein coding gene Chr7:44018608-44036411 (-)
NOD/ShiLtJ ENSMUSG00190047819
 protein coding gene Chr7:34574077-34591880 (-)
NZO/HlLtJ ENSMUSG00225013262
 protein coding gene Chr7:42214908-42233655 (-)
PWK/PhJ ENSLUMG00010048707
 protein coding gene Chr7:33536280-33554819 (-)
SPRET/EiJ ENSMSPG00010031060
 protein coding gene Chr7:33307136-33324636 (-)
WSB/EiJ ENSIUOG00005020314
 protein coding gene Chr7:35121430-35140163 (-)



Homology
more
  • Human Ortholog
    FUT2, fucosyltransferase 2 (H blood group)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FUT2, fucosyltransferase 2 (H blood group)
  • Synonyms
    B12QTL1, SE, Se2, SEC2, sej
  • Links
    NCBI Gene ID: 2524
    UniProt: Q10981

  • Chr Location
    19q13.33; chr19:48695957-48705951 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FUT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype. Females are somewhate more susceptible to infections withCandida albicans.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    692
  • Tissues
    95
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14344 NCBI Gene Model | MGI Sequence Detail 17804 C57BL/6J ±  kb
    transcript NM_001271993 RefSeq | MGI Sequence Detail 3073 ZRU/MplStud  
    polypeptide Q9JL27 UniProt | EBI | MGI Sequence Detail 347 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 6
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38419
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 2
      Gene Ontology 16
      Phenotypes 30
    • Earliest
      J:43607 Domino SE, et al., Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells. Biochem J. 1997 Oct 1;327(Pt 1):105-15
    • Latest
      J:390547 Duan C, et al., Fut2 Deficiency Promotes Intestinal Stem Cell Aging by Damaging Mitochondrial Functions via Down-Regulating alpha1,2-Fucosylation of Asah2 and Npc1. Research (Wash D C). 2024;7:0343
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory