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Krt86 Gene Detail
Summary
  • Symbol
    Krt86
  • Name
    keratin 86
  • Synonyms
    Khb4, Krt2-10, Krt2-11, MHb4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109362
    NCBI Gene: 16679
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101371359-101377864 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109362
 protein coding gene Chr15:101371359-101377867 (+)
129S1/SvImJ ENSMUSG00200050490
 protein coding gene Chr15:98586755-98593272 (+)
A/J ENSMUSG00195041727
 protein coding gene Chr15:98466074-98472592 (+)
AKR/J ENSMUSG00220047175
 protein coding gene Chr15:98450339-98456847 (+)
BALB/cJ ENSMUSG00180036729
 protein coding gene Chr15:98356729-98363246 (+)
C3H/HeJ ENSMUSG00175040297
 protein coding gene Chr15:98646110-98652630 (+)
C57BL/6NJ ENSMUSG00215050617
 protein coding gene Chr15:98412169-98418681 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020314
 protein coding gene Chr15:95172233-95178697 (+)
CAST/EiJ ENSTCUG00005042236
 protein coding gene Chr15:97889651-97896166 (+)
CBA/J ENSMUSG00210031213
 protein coding gene Chr15:98419316-98425836 (+)
DBA/2J ENSMUSG00185041471
 protein coding gene Chr15:98456666-98463174 (+)
FVB/NJ ENSMUSG00205033545
 protein coding gene Chr15:98161156-98167664 (+)
JF1/MsJ ENSUMUG00000049265
 protein coding gene Chr15:97915854-97922379 (+)
LP/J ENSMUSG00230033846
 protein coding gene Chr15:101810056-101816573 (+)
NOD/ShiLtJ ENSMUSG00190048164
 protein coding gene Chr15:98395967-98402475 (+)
NZO/HlLtJ ENSMUSG00225028028
 protein coding gene Chr15:102016538-102023065 (+)
PWK/PhJ ENSLUMG00010041037
 protein coding gene Chr15:98128227-98134740 (+)
SPRET/EiJ ENSMSPG00010034656
 protein coding gene Chr15:99943433-99949905 (+)
WSB/EiJ ENSIUOG00005036449
 protein coding gene Chr15:98551505-98558039 (+)



Homology
more
  • Human Ortholog
    KRT86, keratin 86
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT86, keratin 86
  • Synonyms
    Hb1, HB6, K86, KRTHB1, KRTHB6, MNX, NMLIX1
  • Links
    NCBI Gene ID: 3892
    UniProt: O43790

  • Chr Location
    12q13.13; chr12:52249300-52309163 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human KRT81,KRT83,KRT86 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    3
  • cDNA Data
    6
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16679 NCBI Gene Model | MGI Sequence Detail 6506 C57BL/6J ±  kb
transcript NM_010667 RefSeq | MGI Sequence Detail 1967 C57BL/6  
polypeptide P97861 UniProt | EBI | MGI Sequence Detail 486 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR018039 Intermediate filament protein, conserved site
    IPR039008 Intermediate filament, rod domain
    IPR003054 Keratin, type II
    IPR032444 Keratin type II head
Molecular
Reagents
less
  • All nucleic 19
    Genomic 9
    cDNA 10
    Antibodies 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38407, MGI:2145983
References
more
  • Summaries
    All 65
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 3
    Phenotypes 34
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory