Eif2d MGI Mouse Gene Detail - MGI:109342 - eukaryotic translation initiation factor 2D

Symbol

Eif2d
Name

eukaryotic translation initiation factor 2D
Synonyms

D1Ertd5e, Lgtn

Feature Type

protein coding gene
IDs

MGI:109342
NCBI Gene: 16865
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:131080918-131115395 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.90 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

830 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109342	protein coding gene	Chr1:131080903-131115396 (+)
129S1/SvImJ	ENSMUSG00200008198	protein coding gene	Chr1:128656717-128691355 (+)
A/J	ENSMUSG00195038201	protein coding gene	Chr1:127743190-127777816 (+)
AKR/J	ENSMUSG00220044589	protein coding gene	Chr1:127588821-127623473 (+)
BALB/cJ	ENSMUSG00180030775	protein coding gene	Chr1:128311259-128345951 (+)
C3H/HeJ	ENSMUSG00175036215	protein coding gene	Chr1:127987868-128022533 (+)
C57BL/6NJ	ENSMUSG00215043618	protein coding gene	Chr1:128003595-128038219 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014568	protein coding gene	Chr1:122739110-122771886 (+)
CAST/EiJ	ENSTCUG00005029513	protein coding gene	Chr1:126929461-126964191 (+)
CBA/J	ENSMUSG00210026861	protein coding gene	Chr1:127906105-127940767 (+)
DBA/2J	ENSMUSG00185027188	protein coding gene	Chr1:132255513-132290203 (+)
FVB/NJ	ENSMUSG00205026132	protein coding gene	Chr1:127242521-127277163 (+)
JF1/MsJ	ENSUMUG00000001330	protein coding gene	Chr1:131429037-131462015 (+)
LP/J	ENSMUSG00230001065	protein coding gene	Chr1:131834890-131869524 (+)
NOD/ShiLtJ	ENSMUSG00190030527	protein coding gene	Chr1:127897830-127932448 (+)
NZO/HlLtJ	ENSMUSG00225018662	protein coding gene	Chr1:135571706-135606343 (+)
PWK/PhJ	ENSLUMG00010027038	protein coding gene	Chr1:127035080-127070574 (+)
SPRET/EiJ	ENSMSPG00010040612	protein coding gene	Chr1:129835702-129863767 (+)
WSB/EiJ	ENSIUOG00005045360	protein coding gene	Chr1:127651100-127685873 (+)

Human Ortholog

EIF2D, eukaryotic translation initiation factor 2D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF2D, eukaryotic translation initiation factor 2D
Synonyms

HCA56, LGTN
Links

HGNC:6583

NCBI Gene ID: 1939

UniProt: P41214
Chr Location

1q32.1; chr1:206569146-206612514 (-) GRCh38

MGI Vertebrate Homology

Eif2d stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EIF2D
Gene Tree

Eif2d

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

44
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

40
Radiation induced

1
Genomic Mutations

3 involving Eif2d
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

20

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif2d

ZFIN eif2d

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All Sequences

90
RefSeq

25
UniProt

5
CCDS

CCDS35702.1, CCDS48354.1

Ensembl

ENSMUSG00000026427 (Evidence)
NCBI Gene

16865

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026427	Ensembl Gene Model \| MGI Sequence Detail	34478	C57BL/6J	± kb
transcript	ENSMUST00000131855	Ensembl \| MGI Sequence Detail	3465	Not Applicable
polypeptide	ENSMUSP00000137678	Ensembl \| MGI Sequence Detail	587	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009782 ligatin

(term hierarchy)
InterPro Domains

IPR058886 eIF2D, SWIB domain

IPR057429 eIF2D, winged helix domain

IPR039757 Eukaryotic translation initiation factor 2D

IPR048248 Eukaryotic translation initiation factor 2D-like, PUA RNA-binding domain

IPR048247 Eukaryotic translation initiation factor 2D, N-terminal domain

IPR039759 Eukaryotic translation initiation factor 2D, SUI1 domain

IPR041366 Pre-PUA domain

IPR002478 PUA domain

IPR015947 PUA-like superfamily

IPR001950 SUI1 domain

IPR036877 SUI1 domain superfamily

IPR003121 SWIB/MDM2 domain

IPR036885 SWIB/MDM2 domain superfamily

IPR004521 Uncharacterised domain CHP00451

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All nucleic 25

cDNA 24

Primer pair 1

Microarray probesets 6

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MGD-MRK-38387, MGI:1098717

Summaries

All 37

Gene Ontology 6

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Eif2d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8621	Chr1:131080912-131080923 (+)	0 bp
Tssr8622	Chr1:131080924-131080998 (+)	43 bp
Tssr8623	Chr1:131089003-131089025 (+)	8,096 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24