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Papola Gene Detail
Summary
  • Symbol
    Papola
  • Name
    poly (A) polymerase alpha
  • Synonyms
    PapIII, Plap
  • Feature Type
    protein coding gene
  • IDs
    MGI:109301
    NCBI Gene: 18789
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:105750953-105805203 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 56.06 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1106 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109301
 protein coding gene Chr12:105750926-105805208 (+)
129S1/SvImJ ENSMUSG00200024301
 protein coding gene Chr12:97545791-97545914 (+)
129S1/SvImJ ENSMUSGG00200054855
 protein coding gene Chr12:97521010-97545699 (+)
A/J ENSMUSGG00195054940
 protein coding gene Chr12:100083063-100107752 (+)
A/J ENSMUSG00195016998
 protein coding gene Chr12:100107844-100107967 (+)
AKR/J ENSMUSG00220038540
 protein coding gene Chr12:97985322-97985445 (+)
AKR/J ENSMUSGG00220054626
 protein coding gene Chr12:97960540-97985230 (+)
BALB/cJ ENSMUSG00180034615
 protein coding gene Chr12:99296185-99296308 (+)
BALB/cJ ENSMUSGG00180055322
 protein coding gene Chr12:99271427-99296093 (+)
C3H/HeJ ENSMUSGG00175054793
 protein coding gene Chr12:101900403-101925093 (+)
C3H/HeJ ENSMUSG00175030268
 protein coding gene Chr12:101925185-101925308 (+)
C57BL/6NJ ENSMUSG00215039986
 protein coding gene Chr12:98581727-98581850 (+)
C57BL/6NJ ENSMUSGG00215055642
 protein coding gene Chr12:98556941-98581635 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018093
 protein coding gene Chr12:100247374-100300840 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054619
 protein coding gene Chr12:98962412-98987100 (+)
CBA/J ENSMUSG00210013909
 protein coding gene Chr12:98987192-98987315 (+)
DBA/2J ENSMUSG00185025544
 protein coding gene Chr12:100752844-100752967 (+)
DBA/2J ENSMUSGG00185057613
 protein coding gene Chr12:100728055-100752752 (+)
FVB/NJ ENSMUSG00205014549
 protein coding gene Chr12:97981649-97981772 (+)
FVB/NJ ENSMUSGG00205054473
 protein coding gene Chr12:97956894-97981557 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055434
 protein coding gene Chr12:107786284-107810977 (+)
LP/J ENSMUSG00230026795
 protein coding gene Chr12:107811069-107811192 (+)
NOD/ShiLtJ ENSMUSG00190023983
 protein coding gene Chr12:87228029-87228152 (-)
NOD/ShiLtJ ENSMUSGG00190055018
 protein coding gene Chr12:87228244-87252934 (-)
NZO/HlLtJ ENSMUSGG00225055479
 protein coding gene Chr12:109526463-109551127 (+)
NZO/HlLtJ ENSMUSG00225037065
 protein coding gene Chr12:109551219-109551342 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010017571
 protein coding gene Chr12:101258869-101313132 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PAPOLA, poly(A) polymerase alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAPOLA, poly(A) polymerase alpha
  • Synonyms
    PAP, PAP-alpha
  • Links
    NCBI Gene ID: 10914
    UniProt: P51003

  • Chr Location
    14q32.2; chr14:96501433-96567118 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    699
  • Tissues
    102
  • cDNA Data
    23
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021111 Ensembl Gene Model | MGI Sequence Detail 54251 C57BL/6J ±  kb
    transcript ENSMUST00000109901 Ensembl | MGI Sequence Detail 4380 Not Applicable  
    polypeptide ENSMUSP00000105527 Ensembl | MGI Sequence Detail 739 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • Protein Ontology
      PR:000012267 poly(A) polymerase alpha
      (term hierarchy)
    • EC
      2.7.7.19
    • InterPro Domains
      IPR011068 Nucleotidyltransferase, class I-like, C-terminal
      IPR043519 Nucleotidyltransferase superfamily
      IPR007012 Poly(A) polymerase, central domain
      IPR014492 Poly(A) polymerase, eukaryotic
      IPR048840 Poly(A) polymerase, nucleotidyltransferase domain
      IPR007010 Poly(A) polymerase, RNA-binding domain
    • GlyGen
      Q61183 9 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 24
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-38346
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:33284 Zhao W, et al., Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol. 1996 May;16(5):2378-86
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory