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Slpi Gene Detail
Summary
  • Symbol
    Slpi
  • Name
    secretory leukocyte peptidase inhibitor
  • Feature Type
    protein coding gene
  • IDs
    MGI:109297
    NCBI Gene: 20568
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164195990-164231015 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.16 cM, cytoband H
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1234 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109297
 protein coding gene Chr2:164195990-164231086 (-)
129S1/SvImJ ENSMUSG00200016458
 protein coding gene Chr2:161069232-161071669 (-)
A/J ENSMUSG00195017251
 protein coding gene Chr2:161409638-161412075 (-)
AKR/J ENSMUSG00220013317
 protein coding gene Chr2:160739462-160741896 (-)
BALB/cJ ENSMUSG00180045431
 protein coding gene Chr2:160863400-160865837 (-)
C3H/HeJ ENSMUSG00175049580
 protein coding gene Chr2:161616701-161619135 (-)
C57BL/6NJ ENSMUSG00215018464
 protein coding gene Chr2:161066360-161068797 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024641
 protein coding gene Chr2:156291262-156325906 (-)
CAST/EiJ ENSTCUG00005045211
 protein coding gene Chr2:159984166-159986603 (-)
CBA/J ENSMUSG00210015827
 protein coding gene Chr2:161544104-161546541 (-)
DBA/2J ENSMUSG00185048654
 protein coding gene Chr2:161283902-161286336 (-)
FVB/NJ ENSMUSG00205032755
 protein coding gene Chr2:160304762-160307196 (-)
JF1/MsJ ENSUMUG00000011284
 protein coding gene Chr2:160927033-160929471 (-)
LP/J ENSMUSG00230041303
 protein coding gene Chr2:162838832-162841269 (-)
NOD/ShiLtJ ENSMUSG00190041982
 protein coding gene Chr2:160948956-160951393 (-)
NZO/HlLtJ ENSMUSG00225052048
 protein coding gene Chr2:170846238-170848672 (-)
PWK/PhJ ENSLUMG00010043760
 protein coding gene Chr2:160830715-160833151 (-)
SPRET/EiJ ENSMSPG00010033652
 protein coding gene Chr2:163595677-163597319 (-)
WSB/EiJ ENSIUOG00005041112
 protein coding gene Chr2:160677388-160679822 (-)



Homology
more
  • Human Ortholog
    SLPI, secretory leukocyte peptidase inhibitor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLPI, secretory leukocyte peptidase inhibitor
  • Synonyms
    ALK1, ALP, BLPI, HUSI, HUSI-1, HUSI-I, MPI, WAP4, WFDC4
  • Links
    NCBI Gene ID: 6590
    UniProt: P03973

  • Chr Location
    20q13.12; chr20:45252239-45254564 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice been independently reported to exhibit increased susceptibility to LPS-induced endotoxin shock with elevated production of IL-6, impaired cutaneous wound healing with increased inflammation and elastase activity, and high susceptibility to pulmonary mycobacterial infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    4
  • cDNA Data
    26
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017002 Ensembl Gene Model | MGI Sequence Detail 35026 C57BL/6J ±  kb
transcript ENSMUST00000109367 Ensembl | MGI Sequence Detail 876 Not Applicable  
polypeptide ENSMUSP00000104992 Ensembl | MGI Sequence Detail 131 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    Genomic 1
    cDNA 26
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38342
References
more
  • Summaries
    All 75
    Developmental Gene Expression 6
    Gene Ontology 11
    Phenotypes 21
  • Earliest
    J:38212 Jin FY, et al., Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide. Cell. 1997 Feb 7;88(3):417-26
  • Latest
    J:387261 Yu Q, et al., Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice. Elife. 2025 May 20;14
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory