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Ywhah Gene Detail
Summary
  • Symbol
    Ywhah
  • Name
    tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
  • Synonyms
    14-3-3 eta
  • Feature Type
    protein coding gene
  • IDs
    MGI:109194
    NCBI Gene: 22629
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:33176160-33185310 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.42 cM, cytoband B1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    217 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109194
 protein coding gene Chr5:33176160-33185310 (+)
129S1/SvImJ ENSMUSG00200010049
 protein coding gene Chr5:28643527-28652676 (+)
A/J ENSMUSG00195045042
 protein coding gene Chr5:28116864-28126013 (+)
AKR/J ENSMUSG00220008525
 protein coding gene Chr5:28138882-28148033 (+)
BALB/cJ ENSMUSG00180028479
 protein coding gene Chr5:27921419-27930568 (+)
C3H/HeJ ENSMUSG00175043509
 protein coding gene Chr5:29900998-29910147 (+)
C57BL/6NJ ENSMUSG00215034662
 protein coding gene Chr5:28641811-28650961 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027108
 protein coding gene Chr5:27968857-27977815 (+)
CAST/EiJ ENSTCUG00005023193
 protein coding gene Chr5:28130051-28139197 (+)
CBA/J ENSMUSG00210036681
 protein coding gene Chr5:28868758-28877907 (+)
DBA/2J ENSMUSG00185015851
 protein coding gene Chr5:30732935-30742085 (+)
FVB/NJ ENSMUSG00205016804
 protein coding gene Chr5:27624373-27633523 (+)
JF1/MsJ ENSUMUG00000019598
 protein coding gene Chr5:35323682-35332823 (+)
LP/J ENSMUSG00230042361
 protein coding gene Chr5:35347250-35356399 (+)
NOD/ShiLtJ ENSMUSG00190014374
 protein coding gene Chr5:27896636-27905786 (+)
NZO/HlLtJ ENSMUSG00225016344
 protein coding gene Chr5:40554842-40563991 (+)
PWK/PhJ ENSLUMG00010045779
 protein coding gene Chr5:28039024-28048381 (+)
SPRET/EiJ ENSMSPG00010038249
 protein coding gene Chr5:29207779-29216914 (+)
WSB/EiJ ENSIUOG00005036950
 protein coding gene Chr5:30830356-30839506 (+)



Homology
more
  • Human Ortholog
    YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  • Synonyms
    YWHA1
  • Links
    NCBI Gene ID: 7533
    UniProt: Q04917

  • Chr Location
    22q12.3; chr22:31944522-31957603 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    31 phenotype references
  • All Mutations and Alleles
    22
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Gene trapped
    11
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    6 involving Ywhah
  • Find Mice (IMSR)
    30 strains or lines available
Mice homozygous for a null allele exhibit normal oogenesis, in vitro oocyte maturation and in vivo breeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    182
  • cDNA Data
    254
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22629 NCBI Gene Model | MGI Sequence Detail 9151 C57BL/6J ±  kb
transcript NM_011738 RefSeq | MGI Sequence Detail 1806 C57BL/6  
polypeptide P68510 UniProt | EBI | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 258
    cDNA 254
    Primer pair 3
    Other 1
    Antibodies 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38238
References
more
  • Summaries
    All 94
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 16
    Phenotypes 31
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:378933 Boulan B, et al., Oriented cell divisions induce basal progenitors and regulate neural expansion across tissues and species. Sci Adv. 2026 Feb 6;12(6):eadz6827
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory