Enah MGI Mouse Gene Detail - MGI:108360

Symbol

Enah
Name

ENAH actin regulator
Synonyms

Mena, Ndpp1

Feature Type

protein coding gene
IDs

MGI:108360
NCBI Gene: 13800
Alliance

genome feature page
Transcription Start Sites

14 TSS

Sequence Map

Chr1:181723949-181847555 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 84.93 cM
Mapping Data

3 experiments

SNPs within 2kb

3215 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108360	protein coding gene	Chr1:181723949-181848132 (-)
129S1/SvImJ	ENSMUSG00200021919	protein coding gene	Chr1:179484479-179608116 (-)
A/J	ENSMUSG00195040043	protein coding gene	Chr1:179077946-179201802 (-)
AKR/J	ENSMUSG00220020418	protein coding gene	Chr1:178336636-178460187 (-)
BALB/cJ	ENSMUSG00180033429	protein coding gene	Chr1:179135802-179259443 (-)
C3H/HeJ	ENSMUSG00175033113	protein coding gene	Chr1:179311515-179435143 (-)
C57BL/6NJ	ENSMUSG00215018247	protein coding gene	Chr1:178537242-178660874 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014996	protein coding gene	Chr1:171776154-171891079 (-)
CAST/EiJ	ENSTCUG00005042222	protein coding gene	Chr1:177064134-177188508 (-)
CBA/J	ENSMUSG00210018488	protein coding gene	Chr1:178976522-179100063 (-)
DBA/2J	ENSMUSG00185034127	protein coding gene	Chr1:183595937-183719483 (-)
FVB/NJ	ENSMUSG00205033731	protein coding gene	Chr1:178027069-178150605 (-)
JF1/MsJ	ENSUMUG00000003902	protein coding gene	Chr1:182572157-182695802 (-)
LP/J	ENSMUSG00230029157	protein coding gene	Chr1:183143764-183267394 (-)
NOD/ShiLtJ	ENSMUSG00190032392	protein coding gene	Chr1:178994488-179118341 (-)
NZO/HlLtJ	ENSMUSG00225009710	protein coding gene	Chr1:186897002-187021752 (-)
PWK/PhJ	ENSLUMG00010015945	protein coding gene	Chr1:177838719-177962200 (-)
SPRET/EiJ	ENSMSPG00010032604	protein coding gene	Chr1:181316790-181432502 (-)
WSB/EiJ	ENSIUOG00005010695	protein coding gene	Chr1:178192353-178315899 (-)

Human Ortholog

ENAH, ENAH actin regulator

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ENAH, ENAH actin regulator
Synonyms

ENA, MENA, NDPP1
Links

HGNC:18271

NCBI Gene ID: 55740

UniProt: Q8N8S7
Chr Location

1q42.12; chr1:225486765-225653878 (-) GRCh38

MGI Vertebrate Homology

Enah stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ENAH
Gene Tree

Enah

Diseases

1 with human ENAH associations

				Human Disease	Mouse Models
				stomach cancer IDs stomach cancer DOID:10534 DOID:10539 DOID:10542 DOID:10543 DOID:4713 ICD10CM:C16 ICD10CM:C16.2 ICD10CM:C16.5 ICD10CM:C16.6 ICD9CM:151 ICD9CM:151.4 ICD9CM:151.5 ICD9CM:151.6 ICD9CM:151.9 MESH:D013274 NCI:C194067 NCI:C194069 NCI:C194070 NCI:C3387 NCI:C9331 OMIM:613659 UMLS_CUI:C0024623 UMLS_CUI:C0038356 UMLS_CUI:C0153421 UMLS_CUI:C0153422 UMLS_CUI:C0153423

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
21 phenotypes from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

260
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

253
Targeted

4
Genomic Mutations

2 involving Enah
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

208 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted mutation show defects in major axonal projection pathways in brain, including malformation of the hippocampal commissure and pontocerebellar fibers and frequent agenesis of the corpus callosum due to a failure of axons to project across the midline during development.

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All GO Annotations

47
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

851
Tissues

125
cDNA Data

20
Literature Summary

26

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ENAH

Xenbase enah

ZFIN enah

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All Sequences

112
RefSeq

48
UniProt

7
CCDS

CCDS35811.1, CCDS48473.1, CCDS48474.1, CCDS78764.1

Ensembl

ENSMUSG00000022995 (Evidence)
NCBI Gene

13800

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022995	Ensembl Gene Model \| MGI Sequence Detail	123607	C57BL/6J	± kb
transcript	ENSMUST00000078719	Ensembl \| MGI Sequence Detail	2889	Not Applicable
polypeptide	ENSMUSP00000077781	Ensembl \| MGI Sequence Detail	804	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000007072 protein enabled

(term hierarchy)
PDB

1EVH, 4CC3
InterPro Domains

IPR011993 PH-like domain superfamily

IPR014885 VASP tetramerisation

IPR038023 VASP tetramerisation domain superfamily

IPR000697 WH1/EVH1 domain
GlyGen

Q03173 13 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (8 sites)

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All nucleic 33

cDNA 22

Primer pair 7

Other 4

Antibodies 5

Microarray probesets 6

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MGD-MRK-12800, MGD-MRK-37400, MGI:2138266, MGI:2138537, MGI:97291

Summaries

All 111

Developmental Gene Expression 26

Gene Ontology 15

Phenotypes 26
Earliest

J:3109 Sazuka T, et al., Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein. Biochim Biophys Acta. 1992 Oct 20;1132(3):240-8
Latest

J:381085 Kabir M, et al., A machine learning classifier to identify and prioritise genes associated with murine cardiac development. PLoS Genet. 2026 Feb;22(2):e1011489

TSS for Enah:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15610	Chr1:181847822-181847856 (-)	-284 bp
Tssr15609	Chr1:181847689-181847714 (-)	-147 bp
Tssr15608	Chr1:181847562-181847569 (-)	-11 bp
Tssr15607	Chr1:181847492-181847554 (-)	32 bp
Tssr15606	Chr1:181842054-181842063 (-)	5,496 bp
Tssr15605	Chr1:181842022-181842044 (-)	5,522 bp
Tssr15604	Chr1:181784097-181784112 (-)	63,450 bp
Tssr15603	Chr1:181764780-181764803 (-)	82,763 bp
Tssr15602	Chr1:181764765-181764777 (-)	82,784 bp
Tssr15601	Chr1:181756627-181756632 (-)	90,925 bp
Tssr15600	Chr1:181755322-181755328 (-)	92,230 bp
Tssr15599	Chr1:181746044-181746073 (-)	101,496 bp
Tssr15598	Chr1:181744789-181744808 (-)	102,756 bp
Tssr15597	Chr1:181729057-181729062 (-)	118,495 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24