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Zfp36l2 Gene Detail
Summary
  • Symbol
    Zfp36l2
  • Name
    zinc finger protein 36, C3H type-like 2
  • Synonyms
    Brf2, ERF2, Tis11d
  • Feature Type
    protein coding gene
  • IDs
    MGI:107945
    NCBI Gene: 12193
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:84491359-84495375 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 55.02 cM, cytoband E4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107945
 protein coding gene Chr17:84491352-84495375 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024077
 protein coding gene Chr17:87322560-87331906 (-)
A/J MGP_AJ_G0024036
 protein coding gene Chr17:84572264-84575395 (-)
AKR/J MGP_AKRJ_G0024005
 protein coding gene Chr17:85941859-85947994 (-)
BALB/cJ MGP_BALBcJ_G0024037
 protein coding gene Chr17:84421705-84426776 (-)
C3H/HeJ MGP_C3HHeJ_G0023802
 protein coding gene Chr17:86789896-86794130 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024482
 protein coding gene Chr17:90438623-90441565 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021921
 protein coding gene Chr17:79780902-79784061 (-)
CAST/EiJ MGP_CASTEiJ_G0023281
 protein coding gene Chr17:87558122-87561262 (-)
CBA/J MGP_CBAJ_G0023776
 protein coding gene Chr17:94168136-94172630 (-)
DBA/2J MGP_DBA2J_G0023904
 protein coding gene Chr17:83059244-83063257 (-)
FVB/NJ MGP_FVBNJ_G0023870
 protein coding gene Chr17:82535339-82539870 (-)
LP/J MGP_LPJ_G0023988
 protein coding gene Chr17:88085278-88089314 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023898
 protein coding gene Chr17:94279205-94283224 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024527
 protein coding gene Chr17:86430125-86436102 (-)
PWK/PhJ MGP_PWKPhJ_G0023026
 protein coding gene Chr17:82620624-82622941 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022837
 protein coding gene Chr17:83225713-83231393 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ZFP36L2, ZFP36 ring finger protein like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFP36L2, ZFP36 ring finger protein like 2
  • Synonyms
    BRF2, ERF-2, ERF2, OOMD13, OZEMA13, RNF162C, TIS11D
  • Links
    NCBI Gene ID: 678
    UniProt: P47974

  • Chr Location
    2p21; chr2:43222402-43226606 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice expressing decreased levels of an amino-terminal truncated protein display female infertility whereas mice homozygous for a null allele die within two weeks as a result of hematopoietic system defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    45
  • cDNA Data
    156
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045817 Ensembl Gene Model | MGI Sequence Detail 4017 C57BL/6J ±  kb
    transcript ENSMUST00000060366 Ensembl | MGI Sequence Detail 3530 Not Applicable  
    polypeptide ENSMUSP00000050820 Ensembl | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 163
      Genomic 1
      cDNA 157
      Primer pair 2
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36525
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 17
      Phenotypes 24
    • Earliest
      J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
    • Latest
      J:371318 Saenz-Narciso B, et al., ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasis. Nat Commun. 2025 May 6;16(1):4192
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/30/2025
    MGI 6.24     		The Jackson Laboratory