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Epyc Gene Detail
Summary
  • Symbol
    Epyc
  • Name
    epiphycan
  • Synonyms
    Dspg3, epiphycan, PG-Lb, SLRR3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:107942
    NCBI Gene: 13516
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:97479930-97517770 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 50.35 cM, cytoband C2-C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1396 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107942
 protein coding gene Chr10:97479930-97518316 (+)
129S1/SvImJ ENSMUSG00200019869
 protein coding gene Chr10:93989855-94028240 (+)
A/J ENSMUSG00195015145
 protein coding gene Chr10:94421530-94459916 (+)
AKR/J ENSMUSG00220024919
 protein coding gene Chr10:93977350-94015753 (+)
BALB/cJ ENSMUSG00180008790
 protein coding gene Chr10:94429409-94467793 (+)
C3H/HeJ ENSMUSG00175005828
 protein coding gene Chr10:94324086-94362472 (+)
C57BL/6NJ ENSMUSG00215005324
 protein coding gene Chr10:94012834-94051223 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015759
 protein coding gene Chr10:91322717-91354572 (+)
CAST/EiJ ENSTCUG00005005667
 protein coding gene Chr10:93722845-93761271 (+)
CBA/J ENSMUSG00210022799
 protein coding gene Chr10:94154274-94192659 (+)
DBA/2J ENSMUSG00185018568
 protein coding gene Chr10:94371571-94409957 (+)
FVB/NJ ENSMUSG00205003515
 protein coding gene Chr10:94080411-94118797 (+)
JF1/MsJ ENSUMUG00000018172
 protein coding gene Chr10:95815268-95852592 (+)
LP/J ENSMUSG00230021746
 protein coding gene Chr10:96282196-96320579 (+)
NOD/ShiLtJ ENSMUSG00190024588
 protein coding gene Chr10:94403990-94442375 (+)
NZO/HlLtJ ENSMUSG00225021191
 protein coding gene Chr10:100521885-100560271 (+)
PWK/PhJ ENSLUMG00010005340
 protein coding gene Chr10:94079315-94116648 (+)
SPRET/EiJ ENSMSPG00010009276
 protein coding gene Chr10:95751568-95801123 (+)
WSB/EiJ ENSIUOG00005012567
 protein coding gene Chr10:94118310-94156754 (+)



Homology
more
  • Human Ortholog
    EPYC, epiphycan
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPYC, epiphycan
  • Synonyms
    DSPG3, Pg-Lb, PGLB, SLRR3B
  • Links
    NCBI Gene ID: 1833
    UniProt: Q99645

  • Chr Location
    12q21.33; chr12:90963682-91005026 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out exhibit short femurs and borderline osteoarthritis at 9 months of age. Another null mouse shows elevated hearing thresholds.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    67
  • cDNA Data
    38
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13516 NCBI Gene Model | MGI Sequence Detail 37841 C57BL/6J ±  kb
    transcript NM_001379456 RefSeq | MGI Sequence Detail 1979 ZRU/MplStud  
    polypeptide P70186 UniProt | EBI | MGI Sequence Detail 322 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 4
      cDNA 38
      Primer pair 2
      Other 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36522
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 13
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:343328 Xie Z, et al., ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory