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Stra8 Gene Detail
Summary
  • Symbol
    Stra8
  • Name
    stimulated by retinoic acid gene 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:107917
    NCBI Gene: 20899
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:34897098-34916279 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 15.20 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    699 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107917
 protein coding gene Chr6:34897098-34916279 (+)
129S1/SvImJ ENSMUSG00200042707
 protein coding gene Chr6:31951242-31970439 (+)
A/J ENSMUSG00195035494
 protein coding gene Chr6:31918601-31937785 (+)
AKR/J ENSMUSG00220008727
 protein coding gene Chr6:31519947-31539130 (+)
BALB/cJ ENSMUSG00180044373
 protein coding gene Chr6:32050222-32069407 (+)
C3H/HeJ ENSMUSG00175046366
 protein coding gene Chr6:31917101-31936002 (+)
C57BL/6NJ ENSMUSG00215047243
 protein coding gene Chr6:31951900-31971079 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028215
 protein coding gene Chr6:29704078-29722789 (+)
CAST/EiJ ENSTCUG00005032831
 protein coding gene Chr6:31494183-31514443 (+)
CBA/J ENSMUSG00210052018
 protein coding gene Chr6:31950693-31969593 (+)
DBA/2J ENSMUSG00185042466
 protein coding gene Chr6:32028313-32047495 (+)
FVB/NJ ENSMUSG00205049053
 protein coding gene Chr6:32008867-32027768 (+)
JF1/MsJ ENSUMUG00000019216
 protein coding gene Chr6:31725399-31745046 (+)
LP/J ENSMUSG00230039330
 protein coding gene Chr6:32967527-32986722 (+)
NOD/ShiLtJ ENSMUSG00190035004
 protein coding gene Chr6:31802760-31821942 (+)
NZO/HlLtJ ENSMUSG00225009027
 protein coding gene Chr6:34936923-34956103 (+)
PWK/PhJ ENSLUMG00010037481
 protein coding gene Chr6:31487240-31506798 (+)
SPRET/EiJ ENSMSPG00010027943
 protein coding gene Chr6:32057113-32075193 (+)
WSB/EiJ ENSIUOG00005028836
 protein coding gene Chr6:32103029-32121938 (+)



Homology
more
  • Human Ortholog
    STRA8, stimulated by retinoic acid 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STRA8, stimulated by retinoic acid 8
  • Links
    NCBI Gene ID: 346673
    UniProt: Q7Z7C7

  • Chr Location
    7q33; chr7:135231915-135258663 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 4 alleles in 4 genetic backgrounds
    35 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects meiosis during spermatogenesis and results in male sterility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    986
  • Tissues
    75
  • cDNA Data
    12
  • Literature Summary
    138
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20899 NCBI Gene Model | MGI Sequence Detail 19182 C57BL/6J ±  kb
    transcript NM_009292 RefSeq | MGI Sequence Detail 1468 C57BL/6  
    polypeptide P70278 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 14
      Primer pair 21
      Other 5
      Antibodies 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36497
    References
    more
    • Summaries
      All 275
      Developmental Gene Expression 138
      Gene Ontology 12
      Phenotypes 77
    • Earliest
      J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
    • Latest
      J:391701 Fan X, et al., Deficiency of LARP1 Impairs Spermatogenesis and Leads to Male Subfertility in Mice. FASEB J. 2026 Apr 15;40(7):e71750
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory