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Gp1bb Gene Detail
Summary
  • Symbol
    Gp1bb
  • Name
    glycoprotein Ib, beta polypeptide
  • Feature Type
    protein coding gene
  • IDs
    MGI:107852
    NCBI Gene: 14724
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18439069-18441153 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.53 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107852
 protein coding gene Chr16:18439067-18441153 (-)
129S1/SvImJ ENSMUSG00200041616
 protein coding gene Chr16:15436055-15438141 (-)
A/J ENSMUSG00195034815
 protein coding gene Chr16:14993435-14995521 (-)
AKR/J ENSMUSG00220042645
 protein coding gene Chr16:15309681-15311767 (-)
BALB/cJ ENSMUSG00180030642
 protein coding gene Chr16:15234712-15236798 (-)
C3H/HeJ ENSMUSG00175048107
 protein coding gene Chr16:15379434-15381520 (-)
C57BL/6NJ ENSMUSG00215038417
 protein coding gene Chr16:15100761-15102847 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020550
 protein coding gene Chr16:15107443-15109531 (-)
CAST/EiJ ENSTCUG00005042151
 protein coding gene Chr16:15308004-15310085 (-)
CBA/J ENSMUSG00210032750
 protein coding gene Chr16:15395730-15397816 (-)
DBA/2J ENSMUSG00185031067
 protein coding gene Chr16:15340369-15342455 (-)
FVB/NJ ENSMUSG00205021496
 protein coding gene Chr16:15349900-15351986 (-)
JF1/MsJ ENSUMUG00000018457
 protein coding gene Chr16:15436937-15439023 (-)
LP/J ENSMUSG00230041544
 protein coding gene Chr16:17919758-17921844 (-)
NOD/ShiLtJ ENSMUSG00190043263
 protein coding gene Chr16:15481967-15484053 (-)
NZO/HlLtJ ENSMUSG00225037941
 protein coding gene Chr16:21165583-21167669 (-)
PWK/PhJ ENSLUMG00010043779
 protein coding gene Chr16:15313775-15315861 (-)
SPRET/EiJ ENSMSPG00010035791
 protein coding gene Chr16:15320205-15322285 (-)
WSB/EiJ ENSIUOG00005042193
 protein coding gene Chr16:15475465-15477551 (-)



Homology
more
  • Human Ortholog
    GP1BB, glycoprotein Ib platelet subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GP1BB, glycoprotein Ib platelet subunit beta
  • Synonyms
    BDPLT1, BS, CD42C, GPIBB, GP-Ib beta, GPIbbeta
  • Links
    NCBI Gene ID: 2812
    UniProt: P13224

  • Chr Location
    22q11.21; chr22:19723539-19724776 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gp1bb mouse models; 1 with human GP1BB associations

Human Disease Mouse Models
      
IDs
 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    158 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a significantly smaller than normal number of abnormally large platelets. They also display a severe bleeding phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    679
  • Tissues
    53
  • cDNA Data
    9
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14724 NCBI Gene Model | MGI Sequence Detail 2085 C57BL/6J ±  kb
    transcript NM_001001999 RefSeq | MGI Sequence Detail 2085 Not Specified  
    polypeptide P56400 UniProt | EBI | MGI Sequence Detail 206 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 27
      cDNA 11
      Primer pair 3
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36429
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 9
      Diseases 8
      Gene Ontology 7
      Phenotypes 158
    • Earliest
      J:42557 Kitaguchi T, et al., Characterization of the gene encoding mouse platelet glycoprotien Ib beta. Thromb Res. 1997 Jul 15;87(2):235-44
    • Latest
      J:390319 Son GY, et al., Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome. Cell Rep. 2026 Jul 1;:117619
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory