Stra6 MGI Mouse Gene Detail - MGI:107742 - stimulated by retinoic acid gene 6

Symbol

Stra6
Name

stimulated by retinoic acid gene 6

Feature Type

protein coding gene
IDs

MGI:107742
NCBI Gene: 20897
Alliance

genome feature page
Transcription Start Sites

23 TSS

Sequence Map

Chr9:57971071-58061279 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 31.63 cM, cytoband C
Mapping Data

4 experiments

SNPs within 2kb

2334 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107742	protein coding gene	Chr9:57971071-58061287 (+)
129S1/SvImJ	ENSMUSG00200035421	protein coding gene	Chr9:55113256-55187965 (+)
A/J	ENSMUSG00195038759	protein coding gene	Chr9:54820237-54895081 (+)
AKR/J	ENSMUSG00220027415	protein coding gene	Chr9:54955330-55030150 (+)
BALB/cJ	ENSMUSG00180014939	protein coding gene	Chr9:54927999-55002691 (+)
C3H/HeJ	ENSMUSG00175021188	protein coding gene	Chr9:54947005-55021823 (+)
C57BL/6NJ	ENSMUSG00215025594	protein coding gene	Chr9:54921351-54996027 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032287	protein coding gene	Chr9:54755467-54846808 (+)
CAST/EiJ	ENSTCUG00005019381	protein coding gene	Chr9:54844634-54919899 (+)
CBA/J	ENSMUSG00210038010	protein coding gene	Chr9:55049204-55123923 (+)
DBA/2J	ENSMUSG00185041906	protein coding gene	Chr9:55072427-55147152 (+)
FVB/NJ	ENSMUSG00205020049	protein coding gene	Chr9:55378642-55453466 (+)
JF1/MsJ	ENSUMUG00000020112	protein coding gene	Chr9:55088183-55162898 (+)
LP/J	ENSMUSG00230038510	protein coding gene	Chr9:55312984-55387702 (+)
NOD/ShiLtJ	ENSMUSG00190026622	protein coding gene	Chr9:55139836-55214650 (+)
NZO/HlLtJ	ENSMUSG00225027295	protein coding gene	Chr9:55358536-55433260 (+)
PWK/PhJ	ENSLUMG00010034575	protein coding gene	Chr9:55047019-55121790 (+)
SPRET/EiJ	ENSMSPG00010025339	protein coding gene	Chr9:56087108-56161874 (+)
WSB/EiJ	ENSIUOG00005035607	protein coding gene	Chr9:54552416-54627596 (+)

Human Ortholog

STRA6, signaling receptor and transporter of retinol STRA6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STRA6, signaling receptor and transporter of retinol STRA6
Synonyms

MCOPCB8, MCOPS9, PP14296, SLC69A1
Links

HGNC:30650

NCBI Gene ID: 64220

UniProt: Q9BX79
Chr Location

15q24.1; chr15:74179466-74212267 (-) GRCh38

MGI Vertebrate Homology

Stra6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STRA6
Gene Tree

Stra6

Diseases

1 with human STRA6 associations

				Human Disease	Mouse Models
				syndromic microphthalmia 9 IDs syndromic microphthalmia 9 DOID:0111807 MESH:C537768 OMIM:601186 ORDO:2470 UMLS_CUI:C1832661

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

37 phenotypes from 5 alleles in 6 genetic backgrounds
5 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

4
Gene trapped

12
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a gene trap allele exhibit growth retardation. Mice homozygous for a knock-out allele exhibit persistent hyperplastic primary vitreous, shorter inner and outer segment and reduced rod and cone function.

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All GO Annotations

55
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

955
Tissues

212
cDNA Data

48
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA STRA6

Xenbase stra6

ZFIN stra6

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All Sequences

94
RefSeq

24
UniProt

12
CCDS

CCDS23236.1

Ensembl

ENSMUSG00000032327 (Evidence)
NCBI Gene

20897

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032327	Ensembl Gene Model \| MGI Sequence Detail	90209	C57BL/6J	± kb
transcript	ENSMUST00000085677	Ensembl \| MGI Sequence Detail	2725	Not Applicable
polypeptide	ENSMUSP00000082820	Ensembl \| MGI Sequence Detail	670	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000015772 receptor for retinol uptake STRA6

(term hierarchy)
InterPro Domains

IPR026612 Receptor for retinol uptake STRA6-like
GlyGen

O70491 2 sites

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All nucleic 55

Genomic 1

cDNA 48

Primer pair 5

Other 1

Antibodies 1

Microarray probesets 3

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MGD-MRK-36318, MGI:2143166

Summaries

All 74

Developmental Gene Expression 19

Gene Ontology 8

Phenotypes 19
Earliest

J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
Latest

J:390120 Trowe MO, et al., Mesenchymal WNT signaling coordinates epithelial and mesenchymal differentiation in the developing murine ureter. Cell Commun Signal. 2026 Jul 21;24(1)

TSS for Stra6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85354	Chr9:57986620-57986639 (+)	15,559 bp
Tssr85355	Chr9:57986641-57986665 (+)	15,582 bp
Tssr85356	Chr9:58036345-58036351 (+)	65,277 bp
Tssr85357	Chr9:58036604-58036621 (+)	65,542 bp
Tssr85358	Chr9:58036759-58036767 (+)	65,692 bp
Tssr85359	Chr9:58039171-58039185 (+)	68,107 bp
Tssr85360	Chr9:58041323-58041353 (+)	70,267 bp
Tssr85361	Chr9:58041487-58041511 (+)	70,428 bp
Tssr85362	Chr9:58041525-58041541 (+)	70,462 bp
Tssr85363	Chr9:58041547-58041554 (+)	70,480 bp
Tssr85364	Chr9:58041557-58041564 (+)	70,490 bp
Tssr85365	Chr9:58041571-58041583 (+)	70,506 bp
Tssr85366	Chr9:58041604-58041626 (+)	70,544 bp
Tssr85367	Chr9:58041636-58041643 (+)	70,569 bp
Tssr85368	Chr9:58042001-58042018 (+)	70,939 bp
Tssr85369	Chr9:58042087-58042106 (+)	71,026 bp
Tssr85370	Chr9:58042162-58042174 (+)	71,097 bp
Tssr85371	Chr9:58042178-58042183 (+)	71,110 bp
Tssr85372	Chr9:58042193-58042214 (+)	71,133 bp
Tssr85373	Chr9:58042298-58042312 (+)	71,234 bp
Tssr85374	Chr9:58042327-58042361 (+)	71,273 bp
Tssr85375	Chr9:58042363-58042385 (+)	71,303 bp
Tssr85376	Chr9:58046833-58046837 (+)	75,764 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29