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Plxna1 Gene Detail
Summary
  • Symbol
    Plxna1
  • Name
    plexin A1
  • Synonyms
    2600013D04Rik, NOV, PlexA1, Plxn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107685
    NCBI Gene: 18844
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:89293295-89339595 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    811 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107685
 protein coding gene Chr6:89293295-89339602 (-)
129S1/SvImJ ENSMUSG00200043638
 protein coding gene Chr6:86239921-86281461 (-)
A/J ENSMUSG00195034888
 protein coding gene Chr6:85934169-85975543 (-)
AKR/J ENSMUSG00220027362
 protein coding gene Chr6:84861415-84902819 (-)
BALB/cJ ENSMUSG00180015019
 protein coding gene Chr6:86323555-86364959 (-)
C3H/HeJ ENSMUSG00175024737
 protein coding gene Chr6:91065594-91107134 (+)
C57BL/6NJ ENSMUSG00215022952
 protein coding gene Chr6:86324418-86365822 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028636
 protein coding gene Chr6:85380115-85426150 (-)
CAST/EiJ ENSTCUG00005017816
 protein coding gene Chr6:86220427-86261799 (-)
CBA/J ENSMUSG00210038612
 protein coding gene Chr6:86113155-86154695 (-)
DBA/2J ENSMUSG00185039465
 protein coding gene Chr6:86660443-86701983 (-)
FVB/NJ ENSMUSG00205033873
 protein coding gene Chr6:85286714-85328254 (-)
JF1/MsJ ENSUMUG00000017594
 protein coding gene Chr6:85607859-85649272 (-)
LP/J ENSMUSG00230045748
 protein coding gene Chr6:87795185-87836725 (-)
NOD/ShiLtJ ENSMUSG00190040438
 protein coding gene Chr6:85732258-85773798 (-)
NZO/HlLtJ ENSMUSG00225018816
 protein coding gene Chr6:89815347-89856886 (-)
PWK/PhJ ENSLUMG00010027787
 protein coding gene Chr6:85025517-85066921 (-)
SPRET/EiJ ENSMSPG00010030033
 protein coding gene Chr6:87156920-87203267 (-)
WSB/EiJ ENSIUOG00005029167
 protein coding gene Chr6:86661581-86702955 (-)



Homology
more
  • Human Ortholog
    PLXNA1, plexin A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLXNA1, plexin A1
  • Synonyms
    DWOPNED, NOV, NOVP, PLEXIN-A1, PLXN1
  • Links
    NCBI Gene ID: 5361
    UniProt: Q9UIW2

  • Chr Location
    3q21.3; chr3:126982693-127037389 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit bone cellularity abnormalities, altered dendritic cell physiology, abnormal proprioceptive and oligodendrocyte morphology, and increased lymphatic branching complexity and LEC numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    982
  • Tissues
    280
  • cDNA Data
    204
  • Literature Summary
    67
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18844 NCBI Gene Model | MGI Sequence Detail 46301 C57BL/6J ±  kb
    transcript NM_008881 RefSeq | MGI Sequence Detail 9045 C57BL/6  
    polypeptide P70206 UniProt | EBI | MGI Sequence Detail 1894 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 218
      cDNA 207
      Primer pair 2
      Other 9
      Antibodies 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36260, MGI:1917296
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 67
      Gene Ontology 18
      Phenotypes 44
    • Earliest
      J:35259 Kameyama T, et al., Identification of plexin family molecules in mice. Biochem Biophys Res Commun. 1996 Sep 13;226(2):396-402
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory