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Wbp1l Gene Detail
Summary
  • Symbol
    Wbp1l
  • Name
    WW domain binding protein 1 like
  • Synonyms
    D19Wsu162e
  • Feature Type
    protein coding gene
  • IDs
    MGI:107577
    NCBI Gene: 226178
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:46587545-46645828 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.97 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1798 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107577
 protein coding gene Chr19:46587523-46645828 (+)
129S1/SvImJ ENSMUSG00200020975
 protein coding gene Chr19:43292885-43351523 (+)
A/J ENSMUSG00195014201
 protein coding gene Chr19:43424346-43482780 (+)
AKR/J ENSMUSG00220018548
 protein coding gene Chr19:43229899-43288517 (+)
BALB/cJ ENSMUSG00180019378
 protein coding gene Chr19:43676420-43734855 (+)
C3H/HeJ ENSMUSG00175006396
 protein coding gene Chr19:43222345-43280978 (+)
C57BL/6NJ ENSMUSG00215004212
 protein coding gene Chr19:43285366-43343670 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023041
 protein coding gene Chr19:43266421-43325752 (+)
CAST/EiJ ENSTCUG00005016032
 protein coding gene Chr19:42882086-42940610 (+)
CBA/J ENSMUSG00210018382
 protein coding gene Chr19:43301856-43360484 (+)
DBA/2J ENSMUSG00185007598
 protein coding gene Chr19:43799842-43858272 (+)
FVB/NJ ENSMUSG00205017608
 protein coding gene Chr19:42717289-42775923 (+)
JF1/MsJ ENSUMUG00000022658
 protein coding gene Chr19:43957039-44015923 (+)
LP/J ENSMUSG00230024246
 protein coding gene Chr19:44562511-44621136 (+)
NOD/ShiLtJ ENSMUSG00190004704
 protein coding gene Chr19:43166695-43225293 (+)
NZO/HlLtJ ENSMUSG00225043484
 protein coding gene Chr19:48159138-48217754 (+)
PWK/PhJ ENSLUMG00010000942
 protein coding gene Chr19:43122817-43181501 (+)
SPRET/EiJ ENSMSPG00010006977
 protein coding gene Chr19:42859150-42917770 (+)
WSB/EiJ ENSIUOG00005006417
 protein coding gene Chr19:42671871-42730533 (+)



Homology
more
  • Human Ortholog
    WBP1L, WW domain binding protein 1 like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WBP1L, WW domain binding protein 1 like
  • Synonyms
    C10orf26, OPA1L, OPAL1
  • Links
    NCBI Gene ID: 54838
    UniProt: Q9NX94

  • Chr Location
    10q24.32; chr10:102743948-102834516 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele impaired B cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    684
  • Tissues
    48
  • cDNA Data
    161
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226178 NCBI Gene Model | MGI Sequence Detail 58284 C57BL/6J ±  kb
    transcript NM_001177812 RefSeq | MGI Sequence Detail 3946 ZRU/MplStud  
    polypeptide Q8BGW2 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 162
      cDNA 161
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36149
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:372452 Duric I, et al., WBP1L, a transmembrane adaptor protein involved in the regulation of hematopoiesis, is controlled by CRL1(beta-TrCP) ubiquitin ligases. Biochem Biophys Res Commun. 2025 Feb 16;749:151337
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory