About   Help   FAQ
St6galnac2 Gene Detail
Summary
  • Symbol
    St6galnac2
  • Name
    ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
  • Synonyms
    Siat7, Siat7b, ST6GalNAc II
  • Feature Type
    protein coding gene
  • IDs
    MGI:107553
    NCBI Gene: 20446
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116567529-116586608 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.49 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    626 from dbSNP Build 142
  • Strain Annotations
    36
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107553
 protein coding gene Chr11:116566129-116586608 (-)
129S1/SvImJ ENSMUSG00200049520
 protein coding gene Chr11:113930587-113931970 (-)
129S1/SvImJ ENSMUSG00200049499
 protein coding gene Chr11:113925973-113945549 (-)
A/J ENSMUSG00195025118
 protein coding gene Chr11:113634638-113654199 (-)
A/J ENSMUSG00195025128
 protein coding gene Chr11:113639247-113640630 (-)
AKR/J ENSMUSG00220026274
 protein coding gene Chr11:113737067-113756901 (-)
AKR/J ENSMUSG00220026293
 protein coding gene Chr11:113741945-113743328 (-)
BALB/cJ ENSMUSG00180051405
 protein coding gene Chr11:113932015-113933398 (-)
BALB/cJ ENSMUSG00180051396
 protein coding gene Chr11:113927408-113946979 (-)
C3H/HeJ ENSMUSG00175038524
 protein coding gene Chr11:113886376-113905936 (-)
C3H/HeJ ENSMUSG00175038557
 protein coding gene Chr11:113890984-113892367 (-)
C57BL/6NJ ENSMUSG00215043593
 protein coding gene Chr11:113430965-113432348 (-)
C57BL/6NJ ENSMUSG00215043586
 protein coding gene Chr11:113426361-113445926 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017453
 protein coding gene Chr11:112542759-112562242 (-)
CAST/EiJ ENSTCUG00005027886
 protein coding gene Chr11:113285591-113304877 (-)
CAST/EiJ ENSTCUG00005027907
 protein coding gene Chr11:113290172-113291557 (-)
CBA/J ENSMUSG00210049687
 protein coding gene Chr11:113606355-113625915 (-)
CBA/J ENSMUSG00210049693
 protein coding gene Chr11:113610963-113612346 (-)
DBA/2J ENSMUSG00185022779
 protein coding gene Chr11:113918844-113938412 (-)
DBA/2J ENSMUSG00185022798
 protein coding gene Chr11:113923449-113924832 (-)
FVB/NJ ENSMUSG00205044739
 protein coding gene Chr11:113732430-113752263 (-)
FVB/NJ ENSMUSG00205044795
 protein coding gene Chr11:113737307-113738690 (-)
JF1/MsJ ENSUMUG00000053299
 protein coding gene Chr11:114192796-114194179 (-)
JF1/MsJ ENSUMUG00000053272
 protein coding gene Chr11:114188218-114207499 (-)
LP/J ENSMUSG00230044425
 protein coding gene Chr11:114979624-114999184 (-)
LP/J ENSMUSG00230044447
 protein coding gene Chr11:114984232-114985615 (-)
NOD/ShiLtJ ENSMUSG00190036620
 protein coding gene Chr11:113954186-113955569 (-)
NOD/ShiLtJ ENSMUSG00190036567
 protein coding gene Chr11:113949572-113969149 (-)
NZO/HlLtJ ENSMUSG00225050498
 protein coding gene Chr11:117032540-117033923 (-)
NZO/HlLtJ ENSMUSG00225050496
 protein coding gene Chr11:117027926-117047490 (-)
PWK/PhJ ENSLUMG00010018891
 protein coding gene Chr11:113708951-113710334 (-)
PWK/PhJ ENSLUMG00010018881
 protein coding gene Chr11:113704371-113723654 (-)
SPRET/EiJ ENSMSPG00010038026
 protein coding gene Chr11:114235693-114237076 (-)
SPRET/EiJ ENSMSPG00010037930
 protein coding gene Chr11:114232786-114250422 (-)
WSB/EiJ ENSIUOG00005041975
 protein coding gene Chr11:113696304-113697687 (-)
WSB/EiJ ENSIUOG00005041949
 protein coding gene Chr11:113691694-113711258 (-)



Homology
more
  • Human Ortholog
    ST6GALNAC2, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST6GALNAC2, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
  • Synonyms
    SAITL1, SIAT7, SIAT7B, SIATL1, ST6GalNAII, STHM
  • Links
    NCBI Gene ID: 10610
    UniProt: Q9UJ37

  • Chr Location
    17q25.1; chr17:76565377-76586956 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit decreased body weight, decreased IgQ, increased B cell proliferation, increased pre-B cell number, abnormal erythropoiesis, increased ALT, decreased creatinine level and prominent spleen germinal center.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    108
  • Tissues
    108
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20446 NCBI Gene Model | MGI Sequence Detail 19080 C57BL/6J ±  kb
    transcript NR_199016 RefSeq | MGI Sequence Detail 2134 C57BL/6  
    polypeptide P70277 UniProt | EBI | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 4
      cDNA 9
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36124
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:33752 Kurosawa N, et al., Molecular cloning and genomic analysis of mouse Galbeta1, 3GalNAc-specific GalNAc alpha2,6-sialyltransferase. J Biol Chem. 1996 Jun 21;271(25):15109-16
    • Latest
      J:352184 Ye C, et al., Deletion of Vbeta3(+)CD4(+) T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8(+) T cells. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2312039120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory