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Plcb2 Gene Detail
Summary
  • Symbol
    Plcb2
  • Name
    phospholipase C, beta 2
  • Synonyms
    B230205M18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107465
    NCBI Gene: 18796
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:118537998-118558919 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.43 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    470 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107465
 protein coding gene Chr2:118535484-118559140 (-)
129S1/SvImJ ENSMUSG00200045949
 protein coding gene Chr2:115482758-115503643 (-)
A/J ENSMUSG00195022276
 protein coding gene Chr2:115531011-115551982 (-)
AKR/J ENSMUSG00220035800
 protein coding gene Chr2:115409320-115430233 (-)
BALB/cJ ENSMUSG00180038101
 protein coding gene Chr2:115336144-115357115 (-)
C3H/HeJ ENSMUSG00175024376
 protein coding gene Chr2:115796205-115817100 (-)
C57BL/6NJ ENSMUSG00215028016
 protein coding gene Chr2:115454723-115475639 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024121
 protein coding gene Chr2:111526956-111547688 (-)
CAST/EiJ ENSTCUG00005016259
 protein coding gene Chr2:114735778-114756732 (-)
CBA/J ENSMUSG00210006828
 protein coding gene Chr2:115637172-115658067 (-)
DBA/2J ENSMUSG00185047821
 protein coding gene Chr2:115332839-115353816 (-)
FVB/NJ ENSMUSG00205031728
 protein coding gene Chr2:114547644-114568550 (-)
JF1/MsJ ENSUMUG00000015011
 protein coding gene Chr2:115193215-115214142 (-)
LP/J ENSMUSG00230017404
 protein coding gene Chr2:117142427-117163311 (-)
NOD/ShiLtJ ENSMUSG00190029316
 protein coding gene Chr2:115565528-115586423 (-)
NZO/HlLtJ ENSMUSG00225002398
 protein coding gene Chr2:125043852-125064748 (-)
PWK/PhJ ENSLUMG00010041575
 protein coding gene Chr2:115100243-115119405 (-)
SPRET/EiJ ENSMSPG00010032430
 protein coding gene Chr2:117504780-117525708 (-)
WSB/EiJ ENSIUOG00005026319
 protein coding gene Chr2:115296953-115317867 (-)



Homology
more
  • Human Ortholog
    PLCB2, phospholipase C beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCB2, phospholipase C beta 2
  • Synonyms
    PLC-beta-2
  • Links
    NCBI Gene ID: 5330
    UniProt: Q00722

  • Chr Location
    15q15.1; chr15:40278176-40307941 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 5 genetic backgrounds
    8 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice showed an increased sensitivity to both bacterial and viral infections and exhibited abnormal taste perception in which sweet, umami, and bitter stimuli could not be sensed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    129
  • cDNA Data
    17
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040061 Ensembl Gene Model | MGI Sequence Detail 20922 C57BL/6J ±  kb
    transcript ENSMUST00000102524 Ensembl | MGI Sequence Detail 5145 Not Applicable  
    polypeptide ENSMUSP00000099583 Ensembl | MGI Sequence Detail 1181 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000012829 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
      (term hierarchy)
    • EC
      3.1.4.11
    • InterPro Domains
      IPR028403 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, catalytic domain
      IPR046969 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, EF-hand domain
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR011992 EF-hand domain pair
      IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR053945 Phosphoinositide phospholipase C beta 1-4-like, EF-hand domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR014815 Phospholipase C-beta, C-terminal domain
      IPR042531 Phospholipase C-beta, C-terminal domain superfamily
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR037862 PLC-beta, PH domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 17
      Primer pair 6
      Other 1
      Antibodies 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35937, MGI:2139001, MGI:3036256
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 21
      Gene Ontology 14
      Phenotypes 36
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:385732 Rodriguez Y, et al., Noncanonical Taste Transduction of Sugars Elicits Responses in a Dedicated Subset of Gustatory Afferent Neurons. J Neurosci. 2026 Jan 28;46(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory