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Efna5 Gene Detail
Summary
  • Symbol
    Efna5
  • Name
    ephrin A5
  • Synonyms
    AL-1, EFL-5, Ephrin-A5, Epl7, LERK-7, RAGS
  • Feature Type
    protein coding gene
  • IDs
    MGI:107444
    NCBI Gene: 13640
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
  • Regulated by
    Rr404 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr17:62911179-63188312 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 32.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6736 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107444
 protein coding gene Chr17:62909949-63188431 (-)
129S1/SvImJ ENSMUSG00200016148
 protein coding gene Chr17:58229493-58506461 (-)
A/J ENSMUSG00195007066
 protein coding gene Chr17:59587565-59864756 (-)
AKR/J ENSMUSG00220013274
 protein coding gene Chr17:58668550-58945692 (-)
BALB/cJ ENSMUSG00180005672
 protein coding gene Chr17:59331514-59608708 (-)
C3H/HeJ ENSMUSG00175006705
 protein coding gene Chr17:58649884-58926821 (-)
C57BL/6NJ ENSMUSG00215009035
 protein coding gene Chr17:58297564-58574737 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021820
 protein coding gene Chr17:58877479-59161536 (-)
CAST/EiJ ENSTCUG00005018116
 protein coding gene Chr17:59300959-59579072 (-)
CBA/J ENSMUSG00210027348
 protein coding gene Chr17:58442248-58719129 (-)
DBA/2J ENSMUSG00185022813
 protein coding gene Chr17:61287708-61564858 (-)
FVB/NJ ENSMUSG00205006823
 protein coding gene Chr17:58934913-59212102 (-)
JF1/MsJ ENSUMUG00000032953
 protein coding gene Chr17:60978458-61257886 (-)
LP/J ENSMUSG00230012201
 protein coding gene Chr17:62272103-62549026 (-)
NOD/ShiLtJ ENSMUSG00190010075
 protein coding gene Chr17:58424477-58701584 (-)
NZO/HlLtJ ENSMUSG00225025584
 protein coding gene Chr17:64549916-64827054 (-)
PWK/PhJ ENSLUMG00010008613
 protein coding gene Chr17:58245708-58525204 (-)
SPRET/EiJ ENSMSPG00010005344
 protein coding gene Chr17:58615321-58892407 (-)
WSB/EiJ ENSIUOG00005021110
 protein coding gene Chr17:59263582-59540635 (-)



Homology
more
  • Human Ortholog
    EFNA5, ephrin A5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EFNA5, ephrin A5
  • Synonyms
    AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS
  • Links
    NCBI Gene ID: 1946
    UniProt: P52803

  • Chr Location
    5q21.3; chr5:107376894-107670937 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Efna5 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show defects in establishing axonal connections involving retinal, motor, vomeronasal and tactile axons to their respective targets. Some mice develop neural tube defects. Females show subfertility, impaired response to hCG, follicle rupture defects, and reduced ovulatory capacity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1233
  • Tissues
    381
  • cDNA Data
    21
  • Literature Summary
    116
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048915 Ensembl Gene Model | MGI Sequence Detail 277134 C57BL/6J ±  kb
    transcript ENSMUST00000076840 Ensembl | MGI Sequence Detail 4032 Not Applicable  
    polypeptide ENSMUSP00000076115 Ensembl | MGI Sequence Detail 228 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 26
      Primer pair 4
      Other 14
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35915, MGI:2147024
    References
    more
    • Summaries
      All 224
      Developmental Gene Expression 116
      Diseases 1
      Gene Ontology 20
      Phenotypes 77
    • Earliest
      J:34141 Cerretti DP, et al., The gene encoding LERK-7 (EPLG7, Epl7), a ligand for the Eph-related receptor tyrosine kinases, maps to human chromosome 5 at band q21 and to mouse chromosome 17. Genomics. 1996 Jul 15;35(2):376-9
    • Latest
      J:369942 Sudarsanam S, et al., Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion. J Neurosci. 2025 May 21;45(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory