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Cep131 Gene Detail
Summary
  • Symbol
    Cep131
  • Name
    centrosomal protein 131
  • Synonyms
    AZ1, Azi1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107440
    NCBI Gene: 12009
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:119955256-119977653 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.96 cM, cytoband E2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    636 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107440
 protein coding gene Chr11:119955247-119977684 (-)
129S1/SvImJ ENSMUSG00200052097
 protein coding gene Chr11:117318204-117340606 (-)
A/J ENSMUSG00195029805
 protein coding gene Chr11:116993197-117015597 (-)
AKR/J ENSMUSG00220024634
 protein coding gene Chr11:117143585-117165985 (-)
BALB/cJ ENSMUSG00180047593
 protein coding gene Chr11:117286028-117308391 (-)
C3H/HeJ ENSMUSG00175040021
 protein coding gene Chr11:117243528-117265885 (-)
C57BL/6NJ ENSMUSG00215044840
 protein coding gene Chr11:116813741-116836139 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017506
 protein coding gene Chr11:115970019-115993582 (-)
CAST/EiJ ENSTCUG00005032428
 protein coding gene Chr11:116672557-116694941 (-)
CBA/J ENSMUSG00210049990
 protein coding gene Chr11:116957585-116979922 (-)
DBA/2J ENSMUSG00185025828
 protein coding gene Chr11:117270715-117293072 (-)
FVB/NJ ENSMUSG00205034423
 protein coding gene Chr11:117118812-117141212 (-)
JF1/MsJ ENSUMUG00000037641
 protein coding gene Chr11:117570246-117592701 (-)
LP/J ENSMUSG00230044101
 protein coding gene Chr11:118336518-118358875 (-)
NOD/ShiLtJ ENSMUSG00190048657
 protein coding gene Chr11:117342153-117364553 (-)
NZO/HlLtJ ENSMUSG00225049622
 protein coding gene Chr11:120485784-120508184 (-)
PWK/PhJ ENSLUMG00010020567
 protein coding gene Chr11:117080300-117102695 (-)
SPRET/EiJ ENSMSPG00010032641
 protein coding gene Chr11:117665249-117687870 (-)
WSB/EiJ ENSIUOG00005047777
 protein coding gene Chr11:117084475-117106839 (-)



Homology
more
  • Human Ortholog
    CEP131, centrosomal protein 131
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEP131, centrosomal protein 131
  • Synonyms
    AZ1, AZI1, ZA1
  • Links
    NCBI Gene ID: 22994
    UniProt: Q9UPN4

  • Chr Location
    17q25.3; chr17:81189592-81223014 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit partial preweaning lethality with no apparent defects in cilia formation or function. However, homozygotes display complete male infertility associated with spermiogenesis arrest, severe flagellar defects, and teratozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039781 Ensembl Gene Model | MGI Sequence Detail 22398 C57BL/6J ±  kb
    transcript ENSMUST00000106229 Ensembl | MGI Sequence Detail 3581 Not Applicable  
    polypeptide ENSMUSP00000101836 Ensembl | MGI Sequence Detail 1060 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 3
      cDNA 31

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35911
    References
    more
    • Summaries
      All 34
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:30050 Aoto H, et al., Isolation of a novel cDNA that encodes a protein localized to the pre-acrosome region of spermatids. Eur J Biochem. 1995 Nov 15;234(1):8-15
    • Latest
      J:207969 Chamling X, et al., The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome. PLoS Genet. 2014 Feb;10(2):e1004083
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory