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Numb Gene Detail
Summary
  • Symbol
    Numb
  • Name
    NUMB endocytic adaptor protein
  • Synonyms
    m-numb
  • Feature Type
    protein coding gene
  • IDs
    MGI:107423
    NCBI Gene: 18222
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:83840808-83968708 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 38.89 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2812 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107423
 protein coding gene Chr12:83840808-83968708 (-)
129S1/SvImJ ENSMUSG00200046424
 protein coding gene Chr12:75848252-75976162 (-)
A/J ENSMUSG00195030754
 protein coding gene Chr12:78465867-78593787 (-)
AKR/J ENSMUSG00220048728
 protein coding gene Chr12:76261284-76389193 (-)
BALB/cJ ENSMUSG00180018456
 protein coding gene Chr12:77509842-77637752 (-)
C3H/HeJ ENSMUSG00175037397
 protein coding gene Chr12:80597730-80725630 (-)
C57BL/6NJ ENSMUSG00215044819
 protein coding gene Chr12:76815387-76943310 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017924
 protein coding gene Chr12:78171262-78305126 (-)
CAST/EiJ ENSTCUG00005030270
 protein coding gene Chr12:76757420-76889593 (-)
CBA/J ENSMUSG00210043184
 protein coding gene Chr12:77011944-77139830 (-)
DBA/2J ENSMUSG00185039221
 protein coding gene Chr12:78868448-78996339 (-)
FVB/NJ ENSMUSG00205016195
 protein coding gene Chr12:76679359-76807265 (-)
JF1/MsJ ENSUMUG00000021920
 protein coding gene Chr12:82861469-82993443 (-)
LP/J ENSMUSG00230039449
 protein coding gene Chr12:85930978-86058876 (-)
NOD/ShiLtJ ENSMUSG00190027294
 protein coding gene Chr12:76068341-76196217 (-)
NZO/HlLtJ ENSMUSG00225050504
 protein coding gene Chr12:87971232-88099112 (-)
PWK/PhJ ENSLUMG00010024444
 protein coding gene Chr12:76862943-77002385 (-)
SPRET/EiJ ENSMSPG00010018258
 protein coding gene Chr12:78673292-78811314 (-)
WSB/EiJ ENSIUOG00005044065
 protein coding gene Chr12:76698409-76833963 (-)



Homology
more
  • Human Ortholog
    NUMB, NUMB endocytic adaptor protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUMB, NUMB endocytic adaptor protein
  • Synonyms
    c14_5527, C14orf41, S171
  • Links
    NCBI Gene ID: 8650
    UniProt: P49757

  • Chr Location
    14q24.2-q24.3; chr14:73274146-73466167 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 4 alleles in 5 genetic backgrounds
    35 phenotypes from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die at ~E11.5 with neural tube closure defects and precocious cortical neurogenesis. Mice homozygous for another null allele show impaired axial rotation, neural tube closure, angiogenic remodeling, placenta formation, and motor and sensory neuron differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    98
  • cDNA Data
    81
  • Literature Summary
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18222 NCBI Gene Model | MGI Sequence Detail 127901 C57BL/6J ±  kb
    transcript NM_001411949 RefSeq | MGI Sequence Detail 3684 C57BL/6  
    polypeptide Q9QZS3 UniProt | EBI | MGI Sequence Detail 653 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      Genomic 1
      cDNA 81
      Primer pair 4
      Other 1
      Antibodies 16

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35893
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 66
      Gene Ontology 23
      Phenotypes 60
    • Earliest
      J:34328 Zhong W, et al., Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron. 1996 Jul;17(1):43-53
    • Latest
      J:391656 Zhang S, et al., Numb attenuates LPS-induced neuroinflammation via autophagic regulation of Ifi204 in microglia. Neurobiol Dis. 2026 Apr 8;223:107386
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory