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Adam7 Gene Detail
Summary
  • Symbol
    Adam7
  • Name
    a disintegrin and metallopeptidase domain 7
  • Synonyms
    EAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107247
    NCBI Gene: 11500
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:68734785-68771138 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 35.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1487 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107247
 protein coding gene Chr14:68734785-68771190 (-)
129S1/SvImJ ENSMUSG00200026483
 protein coding gene Chr14:57362729-57398247 (-)
A/J ENSMUSG00195013776
 protein coding gene Chr14:57524970-57561316 (-)
AKR/J ENSMUSG00220026473
 protein coding gene Chr14:56858106-56894460 (-)
BALB/cJ ENSMUSG00180031258
 protein coding gene Chr14:57133631-57169976 (-)
C3H/HeJ ENSMUSG00175032960
 protein coding gene Chr14:58899674-58935185 (-)
C57BL/6NJ ENSMUSG00215013438
 protein coding gene Chr14:57070215-57106565 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019454
 protein coding gene Chr14:59633452-59670603 (-)
CAST/EiJ ENSTCUG00005035053
 protein coding gene Chr14:58777552-58814407 (-)
CBA/J ENSMUSG00210034366
 protein coding gene Chr14:57510061-57546411 (-)
DBA/2J ENSMUSG00185023155
 protein coding gene Chr14:62697542-62733060 (-)
FVB/NJ ENSMUSG00205025572
 protein coding gene Chr14:57019391-57055739 (-)
JF1/MsJ ENSUMUG00000032652
 protein coding gene Chr14:73873119-73908646 (-)
LP/J ENSMUSG00230012678
 protein coding gene Chr14:74726539-74762061 (-)
NOD/ShiLtJ ENSMUSG00190034124
 protein coding gene Chr14:57304811-57341158 (-)
NZO/HlLtJ ENSMUSG00225038478
 protein coding gene Chr14:65032093-65068437 (-)
PWK/PhJ ENSLUMG00010030893
 protein coding gene Chr14:56728529-56764939 (-)
SPRET/EiJ ENSMSPG00010028460
 protein coding gene Chr14:60220796-60260252 (-)
WSB/EiJ ENSIUOG00005035055
 protein coding gene Chr14:56758167-56793768 (-)



Homology
more
  • Human Ortholog
    ADAM7, ADAM metallopeptidase domain 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM7, ADAM metallopeptidase domain 7
  • Synonyms
    ADAM 7, ADAM-7, EAPI, GP-83, GP83
  • Links
    NCBI Gene ID: 8756
    UniProt: Q9H2U9

  • Chr Location
    8p21.2; chr8:24440930-24526970 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced male fertility with decreased cell height in caput epididymis, spermatic granuloma, kinked sperm flagellum and reduced sperm motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11500 NCBI Gene Model | MGI Sequence Detail 36354 C57BL/6J ±  kb
    transcript NM_007402 RefSeq | MGI Sequence Detail 3469 C57BL/6  
    polypeptide O35227 UniProt | EBI | MGI Sequence Detail 789 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 2
      cDNA 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35712
    References
    more
    • Summaries
      All 40
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:17855 Ballock RT, et al., Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. J Cell Physiol. 1994 May;159(2):340-6
    • Latest
      J:226260 Choi H, et al., Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Biol Reprod. 2015 Sep;93(3):70
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory