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Vipr2 Gene Detail
Summary
  • Symbol
    Vipr2
  • Name
    vasoactive intestinal peptide receptor 2
  • Synonyms
    Vip2, VIP receptor subtype 2, VPAC2, VPAC2R
  • Feature Type
    protein coding gene
  • IDs
    MGI:107166
    NCBI Gene: 22355
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:116041346-116109881 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 62.59 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2270 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107166
 protein coding gene Chr12:116041040-116117842 (+)
129S1/SvImJ ENSMUSG00200027223
 protein coding gene Chr12:108402297-108477792 (+)
A/J ENSMUSG00195040024
 protein coding gene Chr12:111109895-111178900 (+)
AKR/J ENSMUSG00220031201
 protein coding gene Chr12:108185657-108254577 (+)
BALB/cJ ENSMUSG00180045715
 protein coding gene Chr12:110907697-110983195 (+)
C3H/HeJ ENSMUSG00175036824
 protein coding gene Chr12:111963305-112032598 (+)
C57BL/6NJ ENSMUSG00215044555
 protein coding gene Chr12:108909242-108977807 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018177
 protein coding gene Chr12:110284663-110354466 (+)
CAST/EiJ ENSTCUG00005037613
 protein coding gene Chr12:108934849-109003279 (+)
CBA/J ENSMUSG00210029634
 protein coding gene Chr12:109239989-109309285 (+)
DBA/2J ENSMUSG00185014468
 protein coding gene Chr12:111744346-111813698 (+)
FVB/NJ ENSMUSG00205033563
 protein coding gene Chr12:110273694-110342617 (+)
JF1/MsJ ENSUMUG00000016806
 protein coding gene Chr12:116036820-116105462 (+)
LP/J ENSMUSG00230042425
 protein coding gene Chr12:118134028-118202575 (+)
NOD/ShiLtJ ENSMUSG00190025957
 protein coding gene Chr12:107770424-107839001 (+)
NZO/HlLtJ ENSMUSG00225041697
 protein coding gene Chr12:119973371-120042284 (+)
PWK/PhJ ENSLUMG00010038246
 protein coding gene Chr12:109095588-109164065 (+)
SPRET/EiJ ENSMSPG00010011535
 protein coding gene Chr12:111914709-111981772 (+)
WSB/EiJ ENSIUOG00005033959
 protein coding gene Chr12:108588201-108657168 (+)



Homology
more
  • Human Ortholog
    VIPR2, vasoactive intestinal peptide receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VIPR2, vasoactive intestinal peptide receptor 2
  • Synonyms
    C16DUPq36.3, DUP7q36.3, PACAP-R-3, PACAP-R3, VIP-R-2, VPAC2, VPAC2R, VPCAP2R
  • Links
    NCBI Gene ID: 7434
    UniProt: P41587

  • Chr Location
    7q36.3; chr7:159028175-159144944 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit enhanced delayed-type hypersensitivity (type IV) and reduced immediate-type hypersensitivity (type I).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    129
  • cDNA Data
    15
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000011171 Ensembl Gene Model | MGI Sequence Detail 68536 C57BL/6J ±  kb
    transcript ENSMUST00000011315 Ensembl | MGI Sequence Detail 3383 Not Applicable  
    polypeptide ENSMUSP00000011315 Ensembl | MGI Sequence Detail 437 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000017301 vasoactive intestinal polypeptide receptor 2
      (term hierarchy)
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR001571 GPCR, family 2, vasoactive intestinal peptide receptor
      IPR002284 GPCR, family 2, vasoactive intestinal peptide receptor 2
      IPR050332 G-protein coupled receptor 2
      IPR047035 Vasoactive intestinal polypeptide receptor 2, 7TM
    • GlyGen
      P41588 3 sites
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 17
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35627
    References
    more
    • Summaries
      All 138
      Developmental Gene Expression 20
      Gene Ontology 8
      Phenotypes 71
    • Earliest
      J:32788 Inagaki N, et al., Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2679-83
    • Latest
      J:390865 Rivera JF, et al., ATLAS: a rationally designed anterograde transsynaptic tracer. Nat Methods. 2025 May;22(5):1101-1111
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory