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Cldn11 Gene Detail
Summary
  • Symbol
    Cldn11
  • Name
    claudin 11
  • Synonyms
    oligodendrocyte-specific protein, Osp, Otm
  • Feature Type
    protein coding gene
  • IDs
    MGI:106925
    NCBI Gene: 18417
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:31204069-31218473 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 15.14 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    518 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106925
 protein coding gene Chr3:31204069-31218475 (+)
129S1/SvImJ ENSMUSG00200023281
 protein coding gene Chr3:27911260-27925647 (+)
A/J ENSMUSG00195020969
 protein coding gene Chr3:27921199-27935607 (+)
AKR/J ENSMUSG00220008299
 protein coding gene Chr3:27958907-27973320 (+)
BALB/cJ ENSMUSG00180030550
 protein coding gene Chr3:28052883-28067283 (+)
C3H/HeJ ENSMUSG00175027044
 protein coding gene Chr3:27914199-27928605 (+)
C57BL/6NJ ENSMUSG00215010097
 protein coding gene Chr3:28307093-28321502 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024911
 protein coding gene Chr3:26200451-26214525 (+)
CAST/EiJ ENSTCUG00005024474
 protein coding gene Chr3:27874443-27888036 (+)
CBA/J ENSMUSG00210033096
 protein coding gene Chr3:28000355-28014763 (+)
DBA/2J ENSMUSG00185009119
 protein coding gene Chr3:26524738-26539135 (-)
FVB/NJ ENSMUSG00205006965
 protein coding gene Chr3:27450078-27464490 (+)
JF1/MsJ ENSUMUG00000002153
 protein coding gene Chr3:27730123-27744368 (+)
LP/J ENSMUSG00230001643
 protein coding gene Chr3:30156746-30171135 (+)
NOD/ShiLtJ ENSMUSG00190030802
 protein coding gene Chr3:28222242-28236654 (+)
NZO/HlLtJ ENSMUSG00225006685
 protein coding gene Chr3:32774576-32788964 (+)
PWK/PhJ ENSLUMG00010032376
 protein coding gene Chr3:27732447-27746674 (+)
SPRET/EiJ ENSMSPG00010023384
 protein coding gene Chr3:28082726-28096425 (+)
WSB/EiJ ENSIUOG00005034569
 protein coding gene Chr3:28245160-28259571 (+)



Homology
more
  • Human Ortholog
    CLDN11, claudin 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN11, claudin 11
  • Synonyms
    HLD22, OSP, OTM
  • Links
    NCBI Gene ID: 5010
    UniProt: O75508

  • Chr Location
    3q26.2; chr3:170418865-170454733 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CLDN11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit tremors, impaired coordination, hindlimb weakness, abnormal myelination of the cranial nerves, increased auditory thresholds, and abnormal stria vascularis. Mutant males have small testes, abnormal seminiferous tubules, and sperm abnormalities resulting in infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    930
  • Tissues
    91
  • cDNA Data
    23
  • Literature Summary
    52
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037625 Ensembl Gene Model | MGI Sequence Detail 14405 C57BL/6J ±  kb
    transcript ENSMUST00000046174 Ensembl | MGI Sequence Detail 1870 Not Applicable  
    polypeptide ENSMUSP00000042181 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 23
      Primer pair 10
      Other 3
      Antibodies 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35386
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 52
      Diseases 1
      Gene Ontology 13
      Phenotypes 23
    • Earliest
      J:33372 Bronstein JM, et al., Chromosomal localization of murine and human oligodendrocyte-specific protein genes. Genomics. 1996 Jun 1;34(2):255-7
    • Latest
      J:379186 Verhaege D, et al., Base barrier cells provide compartmentalization of choroid plexus, brain and CSF. Nat Neurosci. 2026 Feb 12;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory