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Hccs Gene Detail
Summary
  • Symbol
    Hccs
  • Name
    holocytochrome c synthetase
  • Feature Type
    protein coding gene
  • IDs
    MGI:106911
    NCBI Gene: 15159
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:168094526-168103361 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 78.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    342 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106911
 protein coding gene ChrX:168033189-168103368 (-)
129S1/SvImJ ENSMUSG00200013786
 protein coding gene ChrX:144855938-144864780 (-)
A/J ENSMUSG00195016042
 protein coding gene ChrX:149956269-149965111 (-)
AKR/J ENSMUSG00220030408
 protein coding gene ChrX:141842359-141851201 (-)
BALB/cJ ENSMUSG00180017810
 protein coding gene ChrX:145342835-145351677 (-)
C3H/HeJ ENSMUSG00175010162
 protein coding gene ChrX:149889354-149898196 (-)
C57BL/6NJ ENSMUSG00215016025
 protein coding gene ChrX:145715380-145724223 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033584
 protein coding gene ChrX:157307325-157367542 (-)
CAST/EiJ ENSTCUG00005024214
 protein coding gene ChrX:147431303-147440085 (-)
CBA/J ENSMUSG00210028307
 protein coding gene ChrX:147302973-147311815 (-)
DBA/2J ENSMUSG00185029830
 protein coding gene ChrX:162156950-162165792 (-)
FVB/NJ ENSMUSG00205002563
 protein coding gene ChrX:145805570-145814413 (-)
JF1/MsJ ENSUMUG00000010569
 protein coding gene ChrX:182583085-182591864 (-)
LP/J ENSMUSG00230026032
 protein coding gene ChrX:168948722-168957564 (-)
NOD/ShiLtJ ENSMUSG00190021047
 protein coding gene ChrX:146321571-146330413 (-)
NZO/HlLtJ ENSMUSG00225038232
 protein coding gene ChrX:172372250-172381092 (-)
PWK/PhJ ENSLUMG00010001640
 protein coding gene ChrX:143671597-143680439 (-)
SPRET/EiJ ENSMSPG00010025750
 protein coding gene ChrX:149008610-149016327 (-)
WSB/EiJ ENSIUOG00005010918
 protein coding gene ChrX:146715926-146724768 (-)



Homology
more
  • Human Ortholog
    HCCS, holocytochrome c synthase
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCCS, holocytochrome c synthase
  • Synonyms
    CCHL, LSDMCA1, MCOPS7, MLS
  • Links
    NCBI Gene ID: 3052
    UniProt: P53701

  • Chr Location
    Xp22.2; chrX:11111299-11123086 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hccs mouse models; 2 with human HCCS associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 4 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous female or hemizygous males for a conditional allele activated in the heart exhibit fetal lethality associated with abnormal fetal cardiomyocyte morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    651
  • Tissues
    49
  • cDNA Data
    35
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15159 NCBI Gene Model | MGI Sequence Detail 8836 C57BL/6J ±  kb
    transcript NM_001410431 RefSeq | MGI Sequence Detail 2737 C57BL/6  
    polypeptide P53702 UniProt | EBI | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 2
      cDNA 35
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35372
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 12
      Phenotypes 8
    • Earliest
      J:38101 Limbach KJ, et al., Characterization of a mouse somatic cytochrome c gene and three cytochrome c pseudogenes. Nucleic Acids Res. 1985 Jan 25;13(2):617-30
    • Latest
      J:284250 Hennig M, et al., Dietary protein restriction throughout intrauterine and postnatal life results in potentially beneficial myocardial tissue remodeling in the adult mouse heart. Sci Rep. 2019 Oct 22;9(1):15126
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory