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Pon3 Gene Detail
Summary
  • Symbol
    Pon3
  • Name
    paraoxonase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106686
    NCBI Gene: 269823
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:5220852-5256286 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 1.99 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1065 from dbSNP Build 142
  • Strain Annotations
    30
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106686
 protein coding gene Chr6:5216253-5256286 (-)
129S1/SvImJ ENSMUSG00200001210
 protein coding gene Chr6:2308724-2317313 (-)
129S1/SvImJ ENSMUSGG00200054531
 protein coding gene Chr6:2322391-2332763 (-)
A/J ENSMUSG00195001870
 protein coding gene Chr6:2179181-2199403 (-)
A/J ENSMUSGG00195055304
 protein coding gene Chr6:2203679-2214050 (-)
AKR/J ENSMUSG00220020345
 protein coding gene Chr6:2086500-2106724 (-)
AKR/J ENSMUSGG00220054603
 protein coding gene Chr6:2110998-2121369 (-)
BALB/cJ ENSMUSG00180001475
 protein coding gene Chr6:2314732-2334955 (-)
BALB/cJ ENSMUSGG00180055046
 protein coding gene Chr6:2339229-2349600 (-)
C3H/HeJ ENSMUSG00175007201
 protein coding gene Chr6:2143232-2163454 (-)
C3H/HeJ ENSMUSGG00175055021
 protein coding gene Chr6:2167726-2178097 (-)
C57BL/6NJ ENSMUSGG00215055584
 protein coding gene Chr6:2298938-2309123 (-)
C57BL/6NJ ENSMUSG00215009295
 protein coding gene Chr6:2274452-2294667 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028081
 protein coding gene Chr6:1699004-1728429 (-)
CAST/EiJ ENSTCUG00005025886
 protein coding gene Chr6:2162013-2182065 (-)
CBA/J ENSMUSGG00210054492
 protein coding gene Chr6:2104791-2115162 (-)
CBA/J ENSMUSG00210021110
 protein coding gene Chr6:2080292-2100515 (-)
DBA/2J ENSMUSGG00185057417
 protein coding gene Chr6:2299577-2309948 (-)
DBA/2J ENSMUSG00185023859
 protein coding gene Chr6:2275081-2295303 (-)
FVB/NJ ENSMUSGG00205054379
 protein coding gene Chr6:2319092-2329465 (-)
FVB/NJ ENSMUSG00205013482
 protein coding gene Chr6:2294592-2314816 (-)
JF1/MsJ ENSUMUG00000008594
 protein coding gene Chr6:2282301-2302350 (-)
LP/J ENSMUSGG00230055842
 protein coding gene Chr6:3299288-3309659 (-)
LP/J ENSMUSG00230014163
 protein coding gene Chr6:3274792-3295014 (-)
NOD/ShiLtJ ENSMUSGG00190054847
 protein coding gene Chr6:2024801-2035172 (-)
NOD/ShiLtJ ENSMUSG00190015757
 protein coding gene Chr6:2000303-2020525 (-)
NZO/HlLtJ ENSMUSGG00225055165
 protein coding gene Chr6:5134114-5144485 (-)
NZO/HlLtJ ENSMUSG00225017658
 protein coding gene Chr6:5109616-5129838 (-)
PWK/PhJ ENSLUMG00010022516
 protein coding gene Chr6:2071742-2091835 (-)
SPRET/EiJ ENSMSPG00010002360
 protein coding gene Chr6:1967137-1987031 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PON3, paraoxonase 3
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PON3, paraoxonase 3
  • Links
    NCBI Gene ID: 5446
    UniProt: Q15166

  • Chr Location
    7q21.3; chr7:95357618-95396493 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human PON3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show prenatal and postnatal lethality. Homozygotes for a different null allele are viable but show altered lipid and bile acid metabolism, impaired mitochondrial respiration, and increased susceptibility to diet-induced atherosclerosis, gallstone formation, and obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    148
  • cDNA Data
    44
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029759 Ensembl Gene Model | MGI Sequence Detail 35435 C57BL/6J ±  kb
    transcript ENSMUST00000031773 Ensembl | MGI Sequence Detail 1837 Not Applicable  
    polypeptide ENSMUSP00000031773 Ensembl | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 45
      Primer pair 5
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35145, MGI:2141470
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:32894 Primo-Parmo SL, et al., The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics. 1996 May 1;33(3):498-507
    • Latest
      J:368079 Whelan SCM, et al., Paraoxonase 3 regulates the pore-forming alpha subunit of the large-conductance K(+) channel. Biochim Biophys Acta Mol Cell Res. 2025 Aug;1872(6):119990
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory