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Tpgs1 Gene Detail
Summary
  • Symbol
    Tpgs1
  • Name
    tubulin polyglutamylase complex subunit 1
  • Synonyms
    Gm16517, Gtrgeo22
  • Feature Type
    protein coding gene
  • IDs
    MGI:106618
    NCBI Gene: 110012
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:79505273-79511961 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106618
 protein coding gene Chr10:79505203-79511961 (+)
129S1/SvImJ ENSMUSG00200041934
 protein coding gene Chr10:76128871-76135630 (+)
A/J ENSMUSG00195041282
 protein coding gene Chr10:76524372-76531131 (+)
AKR/J ENSMUSG00220038115
 protein coding gene Chr10:76121946-76128705 (+)
BALB/cJ ENSMUSG00180050781
 protein coding gene Chr10:76534873-76541631 (+)
C3H/HeJ ENSMUSG00175051670
 protein coding gene Chr10:76405571-76412331 (+)
C57BL/6NJ ENSMUSG00215052590
 protein coding gene Chr10:76147248-76154008 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015533
 protein coding gene Chr10:73647208-73654429 (+)
CAST/EiJ ENSTCUG00005048413
 protein coding gene Chr10:76031728-76038462 (+)
CBA/J ENSMUSG00210046240
 protein coding gene Chr10:76261659-76268417 (+)
DBA/2J ENSMUSG00185051133
 protein coding gene Chr10:76604032-76610791 (+)
FVB/NJ ENSMUSG00205027453
 protein coding gene Chr10:76316819-76323577 (+)
JF1/MsJ ENSUMUG00000050897
 protein coding gene Chr10:77834614-77841326 (+)
LP/J ENSMUSG00230050436
 protein coding gene Chr10:78373806-78380564 (+)
NOD/ShiLtJ ENSMUSG00190044511
 protein coding gene Chr10:76517869-76524627 (+)
NZO/HlLtJ ENSMUSG00225050676
 protein coding gene Chr10:82660269-82667027 (+)
PWK/PhJ ENSLUMG00010050456
 protein coding gene Chr10:76193990-76200696 (+)
SPRET/EiJ ENSMSPG00010044687
 protein coding gene Chr10:77813171-77819888 (+)
WSB/EiJ ENSIUOG00005048015
 protein coding gene Chr10:76221428-76228185 (+)



Homology
more
  • Human Ortholog
    TPGS1, tubulin polyglutamylase complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPGS1, tubulin polyglutamylase complex subunit 1
  • Synonyms
    C19orf20, GTRGEO22, PGs1
  • Links
    NCBI Gene ID: 91978
    UniProt: Q6ZTW0

  • Chr Location
    19p13.3; chr19:507497-519654 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a gene trapped allele are sterile due to abnormal development of the spermatid flagellum. Adult males display a striking deficit in intermale aggression and reduced body fat, not due to an altered resting metabolic rate or hypophagia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110012 NCBI Gene Model | MGI Sequence Detail 6689 C57BL/6J ±  kb
    transcript NM_148934 RefSeq | MGI Sequence Detail 1073 ZRU/MplStud  
    polypeptide Q99MS8 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000031177 tubulin polyglutamylase complex subunit 1
      (term hierarchy)
    • InterPro Domains
      IPR039235 Tubulin polyglutamylase complex subunit 1
      IPR047502 Tubulin polyglutamylase complex subunit 1, dimerization/docking domain
      IPR057632 Tubulin polyglutamylase complex subunit 1-like, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 38
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35075
    References
    more
    • Summaries
      All 42
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory