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Hivep3 Gene Detail
Summary
  • Symbol
    Hivep3
  • Name
    human immunodeficiency virus type I enhancer binding protein 3
  • Synonyms
    2900056N03Rik, E030045D18Rik, Krc, Schnurri-3, Shn3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106589
    NCBI Gene: 16656
  • Alliance
    genome feature page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:119590982-119992608 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 55.51 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10235 from dbSNP Build 142
  • Strain Annotations
    24
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106589
 protein coding gene Chr4:119590981-119995242 (+)
129S1/SvImJ ENSMUSG00200014165
 protein coding gene Chr4:113852197-113895956 (+)
A/J ENSMUSG00195028218
 protein coding gene Chr4:115091655-115135411 (+)
AKR/J ENSMUSG00220021150
 protein coding gene Chr4:114102662-114105635 (+)
AKR/J ENSMUSG00220021158
 protein coding gene Chr4:114463534-114507293 (+)
BALB/cJ ENSMUSG00180042311
 protein coding gene Chr4:113155098-113195508 (+)
C3H/HeJ ENSMUSG00175022844
 protein coding gene Chr4:114168228-114208643 (+)
C57BL/6NJ ENSMUSG00215016041
 protein coding gene Chr4:114929047-114932019 (+)
C57BL/6NJ ENSMUSG00215016067
 protein coding gene Chr4:115289924-115333692 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026406
 protein coding gene Chr4:110281106-110686752 (+)
CAST/EiJ ENSTCUG00005042616
 protein coding gene Chr4:113967306-114008137 (+)
CBA/J ENSMUSG00210051863
 protein coding gene Chr4:113774700-113815152 (+)
DBA/2J ENSMUSG00185045374
 protein coding gene Chr4:115326590-115370341 (+)
FVB/NJ ENSMUSG00205013906
 protein coding gene Chr4:112883521-112886499 (+)
FVB/NJ ENSMUSG00205013917
 protein coding gene Chr4:113245623-113289344 (+)
JF1/MsJ ENSUMUG00000014540
 protein coding gene Chr4:115236158-115278826 (+)
LP/J ENSMUSG00230043309
 protein coding gene Chr4:118669918-118713674 (+)
NOD/ShiLtJ ENSMUSG00190026717
 protein coding gene Chr4:113168097-113208520 (+)
NOD/ShiLtJ ENSMUSG00190026691
 protein coding gene Chr4:112807010-112809982 (+)
NZO/HlLtJ ENSMUSG00225014552
 protein coding gene Chr4:123860084-123863056 (+)
NZO/HlLtJ ENSMUSG00225014593
 protein coding gene Chr4:124220914-124264663 (+)
PWK/PhJ ENSLUMG00010039401
 protein coding gene Chr4:112652100-112693025 (+)
SPRET/EiJ ENSMSPG00010032815
 protein coding gene Chr4:114729673-114769836 (+)
WSB/EiJ ENSIUOG00005037483
 protein coding gene Chr4:113461547-113505314 (+)



Homology
more
  • Human Ortholog
    HIVEP3, HIVEP zinc finger 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIVEP3, HIVEP zinc finger 3
  • Synonyms
    KBP-1, KBP1, KRC, Schnurri-3, SHN3, ZAS3, ZNF40C
  • Links
    NCBI Gene ID: 59269
    UniProt: Q5T1R4

  • Chr Location
    1p34.2; chr1:41506365-42035934 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    6 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in diminished IL-2 production by stimulated CD4 cells. Mice homozygous for a knock-out allele exhibit increased bone volume.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    689
  • Tissues
    61
  • cDNA Data
    19
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16656 NCBI Gene Model | MGI Sequence Detail 401627 C57BL/6J ±  kb
    transcript NM_010657 RefSeq | MGI Sequence Detail 9021 Not Specified  
    polypeptide A2A884 UniProt | EBI | MGI Sequence Detail 2348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 2
      cDNA 20
      Primer pair 2
      Other 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-35045, MGI:1920253, MGI:2140378, MGI:2443550
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 28
    • Earliest
      J:15696 Wu LC, et al., Molecular cloning of a zinc finger protein which binds to the heptamer of the signal sequence for V(D)J recombination. Nucleic Acids Res. 1993 Nov 11;21(22):5067-73
    • Latest
      J:367440 Sun L, et al., Transcriptomic insights into fate choice of pallial versus subpallial GABAergic neurons. Nat Commun. 2025 May 30;16(1):5032
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory