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Rfx2 Gene Detail
Summary
  • Symbol
    Rfx2
  • Name
    regulatory factor X, 2 (influences HLA class II expression)
  • Synonyms
    5430432H19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:106583
    NCBI Gene: 19725
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57082897-57138013 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.50 cM, cytoband D
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1180 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106583
 protein coding gene Chr17:57082897-57138102 (-)
129S1/SvImJ ENSMUSG00200016449
 protein coding gene Chr17:52358546-52413646 (-)
A/J ENSMUSG00195006742
 protein coding gene Chr17:53746276-53801394 (-)
AKR/J ENSMUSG00220012118
 protein coding gene Chr17:52795608-52850728 (-)
BALB/cJ ENSMUSG00180005775
 protein coding gene Chr17:53503916-53559039 (-)
C3H/HeJ ENSMUSG00175007300
 protein coding gene Chr17:52819914-52875029 (-)
C57BL/6NJ ENSMUSG00215008033
 protein coding gene Chr17:52434073-52489193 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021791
 protein coding gene Chr17:53364258-53420024 (-)
CAST/EiJ ENSTCUG00005019093
 protein coding gene Chr17:53550619-53606161 (-)
CBA/J ENSMUSG00210028193
 protein coding gene Chr17:52586993-52642092 (-)
DBA/2J ENSMUSG00185007837
 protein coding gene Chr17:55456837-55511953 (-)
FVB/NJ ENSMUSG00205006775
 protein coding gene Chr17:53134252-53189353 (-)
JF1/MsJ ENSUMUG00000032091
 protein coding gene Chr17:55143992-55198994 (-)
LP/J ENSMUSG00230025827
 protein coding gene Chr17:56435915-56491012 (-)
NOD/ShiLtJ ENSMUSG00190009339
 protein coding gene Chr17:52589470-52644564 (-)
NZO/HlLtJ ENSMUSG00225042619
 protein coding gene Chr17:58720018-58775135 (-)
PWK/PhJ ENSLUMG00010008494
 protein coding gene Chr17:52394547-52449518 (-)
SPRET/EiJ ENSMSPG00010005484
 protein coding gene Chr17:52712204-52767722 (-)
WSB/EiJ ENSIUOG00005021845
 protein coding gene Chr17:53495265-53550465 (-)



Homology
more
  • Human Ortholog
    RFX2, regulatory factor X2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RFX2, regulatory factor X2
  • Links
    NCBI Gene ID: 5990
    UniProt: P48378

  • Chr Location
    19p13.3; chr19:5993164-6199572 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 4 alleles in 4 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations in this gene result in viable mice that lack an obvious embryonic phenotype but exhibit male infertility associated with arrested spermatid differentiation and formation of multinucleated giant male germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    849
  • Tissues
    174
  • cDNA Data
    33
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024206 Ensembl Gene Model | MGI Sequence Detail 55117 C57BL/6J ±  kb
    transcript ENSMUST00000002444 Ensembl | MGI Sequence Detail 3350 Not Applicable  
    polypeptide ENSMUSP00000002444 Ensembl | MGI Sequence Detail 717 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 34
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35039, MGI:1918654
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 18
      Gene Ontology 14
      Phenotypes 12
    • Earliest
      J:32459 Reith W, et al., RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol Cell Biol. 1994 Feb;14(2):1230-44
    • Latest
      J:380157 Feng G, et al., CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions. Adv Sci (Weinh). 2026 Feb;13(12):e08697
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory