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Tomm70a Gene Detail
Summary
  • Symbol
    Tomm70a
  • Name
    translocase of outer mitochondrial membrane 70A
  • Synonyms
    2610044B22Rik, D16Ium22, D16Ium22e, D16Wsu109e, mKIAA0719, Tom70, Tomm70a
  • Feature Type
    protein coding gene
  • IDs
    MGI:106295
    NCBI Gene: 28185
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:56942077-56974893 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 34.22 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    810 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106295
 protein coding gene Chr16:56942066-56977068 (+)
129S1/SvImJ ENSMUSG00200020820
 protein coding gene Chr16:53864101-53899021 (+)
A/J ENSMUSG00195024678
 protein coding gene Chr16:53493909-53528819 (+)
AKR/J ENSMUSG00220019114
 protein coding gene Chr16:53850283-53885296 (+)
BALB/cJ ENSMUSG00180021211
 protein coding gene Chr16:53665784-53700704 (+)
C3H/HeJ ENSMUSG00175016986
 protein coding gene Chr16:53941795-53976803 (+)
C57BL/6NJ ENSMUSG00215018578
 protein coding gene Chr16:53748464-53783468 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020820
 protein coding gene Chr16:53509519-53542960 (+)
CAST/EiJ ENSTCUG00005013090
 protein coding gene Chr16:53950146-53985402 (+)
CBA/J ENSMUSG00210019575
 protein coding gene Chr16:53936886-53971877 (+)
DBA/2J ENSMUSG00185024148
 protein coding gene Chr16:53843338-53878256 (+)
FVB/NJ ENSMUSG00205009539
 protein coding gene Chr16:53611474-53646390 (+)
JF1/MsJ ENSUMUG00000024385
 protein coding gene Chr16:54049585-54084589 (+)
LP/J ENSMUSG00230005974
 protein coding gene Chr16:56387257-56422168 (+)
NOD/ShiLtJ ENSMUSG00190006972
 protein coding gene Chr16:53864053-53899061 (+)
NZO/HlLtJ ENSMUSG00225025468
 protein coding gene Chr16:59486103-59521017 (+)
PWK/PhJ ENSLUMG00010011414
 protein coding gene Chr16:53869602-53904656 (+)
SPRET/EiJ ENSMSPG00010001453
 protein coding gene Chr16:54368471-54399306 (+)
WSB/EiJ ENSIUOG00005008854
 protein coding gene Chr16:54064466-54099386 (+)



Homology
more
  • Human Ortholog
    TOMM70, translocase of outer mitochondrial membrane 70
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOMM70, translocase of outer mitochondrial membrane 70
  • Synonyms
    Tom70, TOMM70A
  • Links
    NCBI Gene ID: 9868
    UniProt: O94826

  • Chr Location
    3q12.2; chr3:100363431-100401111 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    100
  • cDNA Data
    230
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 28185 NCBI Gene Model | MGI Sequence Detail 32817 C57BL/6J ±  kb
    transcript NM_138599 RefSeq | MGI Sequence Detail 3778 ZRU/MplStud  
    polypeptide Q9CZW5 UniProt | EBI | MGI Sequence Detail 611 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016541 mitochondrial import receptor subunit TOM70
      (term hierarchy)
    • InterPro Domains
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
    • GlyGen
      Q9CZW5 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 233
      cDNA 230
      Primer pair 2
      Other 1
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33852, MGD-MRK-33987, MGI:106165, MGI:1917299
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:34963 Wei J, et al., Direct cDNA selection with DNA microdissected from mouse chromosome 16: isolation of novel clones and construction of a partial transcription map of the C3-C4 region. Genome Res. 1996 Aug;6(8):678-87
    • Latest
      J:377026 Deng Q, et al., N-terminal alpha-amino SUMOylation promotes phosphorylation-independent cofilin-1 translocation to the mitochondrial matrix and induces apoptosis. Nat Commun. 2025 Nov 27;16(1):11687
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory