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Lrrn2 Gene Detail
Summary
  • Symbol
    Lrrn2
  • Name
    leucine rich repeat protein 2, neuronal
  • Synonyms
    5730406J09Rik, NLRR-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:106037
    NCBI Gene: 16980
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:132808093-132867743 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.69 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1648 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106037
 protein coding gene Chr1:132808011-132867743 (+)
129S1/SvImJ ENSMUSG00200006622
 protein coding gene Chr1:130369861-130429581 (+)
A/J ENSMUSG00195044136
 protein coding gene Chr1:129474814-129534564 (+)
AKR/J ENSMUSG00220049863
 protein coding gene Chr1:129299982-129361886 (+)
BALB/cJ ENSMUSG00180033447
 protein coding gene Chr1:130020317-130080073 (+)
C3H/HeJ ENSMUSG00175038366
 protein coding gene Chr1:129719295-129779030 (+)
C57BL/6NJ ENSMUSG00215042034
 protein coding gene Chr1:129733169-129792906 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014592
 protein coding gene Chr1:124483146-124544313 (+)
CAST/EiJ ENSTCUG00005028215
 protein coding gene Chr1:128639383-128700355 (+)
CBA/J ENSMUSG00210025367
 protein coding gene Chr1:129615028-129674774 (+)
DBA/2J ENSMUSG00185031966
 protein coding gene Chr1:133968641-134028384 (+)
FVB/NJ ENSMUSG00205028976
 protein coding gene Chr1:128951481-129011236 (+)
JF1/MsJ ENSUMUG00000024267
 protein coding gene Chr1:133135921-133197236 (+)
LP/J ENSMUSG00230037302
 protein coding gene Chr1:133558140-133617887 (+)
NOD/ShiLtJ ENSMUSG00190033241
 protein coding gene Chr1:129629295-129689032 (+)
NZO/HlLtJ ENSMUSG00225016652
 protein coding gene Chr1:137280223-137339957 (+)
PWK/PhJ ENSLUMG00010025368
 protein coding gene Chr1:128752158-128813458 (+)
SPRET/EiJ ENSMSPG00010043803
 protein coding gene Chr1:131607136-131610155 (+)
WSB/EiJ ENSIUOG00005041626
 protein coding gene Chr1:129362460-129422124 (+)



Homology
more
  • Human Ortholog
    LRRN2, leucine rich repeat neuronal 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRN2, leucine rich repeat neuronal 2
  • Synonyms
    FIGLER7, GAC1, LRANK1, LRRN5
  • Links
    NCBI Gene ID: 10446
    UniProt: O75325

  • Chr Location
    1q32.1; chr1:204617170-204685738 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibited numerous neurological abnormalities when compared with controls.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    831
  • Tissues
    72
  • cDNA Data
    37
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16980 NCBI Gene Model | MGI Sequence Detail 59651 C57BL/6J ±  kb
transcript NM_010732 RefSeq | MGI Sequence Detail 3346 C57BL/6  
polypeptide NP_034862 RefSeq | MGI Sequence Detail 730 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 37
    Primer pair 1
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-33721, MGI:1925383
References
more
  • Summaries
    All 39
    Developmental Gene Expression 7
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory