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Bst1 Gene Detail
Summary
  • Symbol
    Bst1
  • Name
    bone marrow stromal cell antigen 1
  • Synonyms
    114/A10, Bp3, Bsta1, CD157, Ly65
  • Feature Type
    protein coding gene
  • IDs
    MGI:105370
    NCBI Gene: 12182
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:43976235-44000810 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 23.84 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    721 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105370
 protein coding gene Chr5:43976227-44001328 (+)
129S1/SvImJ ENSMUSG00200029358
 protein coding gene Chr5:39467548-39492649 (+)
A/J ENSMUSG00195029112
 protein coding gene Chr5:38872901-38898003 (+)
AKR/J ENSMUSG00220001956
 protein coding gene Chr5:38909625-38934728 (+)
BALB/cJ ENSMUSG00180023320
 protein coding gene Chr5:38707590-38725430 (+)
C3H/HeJ ENSMUSG00175018279
 protein coding gene Chr5:40668584-40693685 (+)
C57BL/6NJ ENSMUSG00215004824
 protein coding gene Chr5:39427342-39452446 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027195
 protein coding gene Chr5:38218063-38236071 (+)
CAST/EiJ ENSTCUG00005022732
 protein coding gene Chr5:38804042-38821936 (+)
CBA/J ENSMUSG00210004527
 protein coding gene Chr5:39633692-39658794 (+)
DBA/2J ENSMUSG00185001384
 protein coding gene Chr5:41515909-41533757 (+)
FVB/NJ ENSMUSG00205016566
 protein coding gene Chr5:38425743-38443590 (+)
JF1/MsJ ENSUMUG00000001742
 protein coding gene Chr5:46093628-46111428 (+)
LP/J ENSMUSG00230002111
 protein coding gene Chr5:46167469-46192570 (+)
NOD/ShiLtJ ENSMUSG00190002685
 protein coding gene Chr5:38708461-38733561 (+)
NZO/HlLtJ ENSMUSG00225028235
 protein coding gene Chr5:51322872-51347949 (+)
PWK/PhJ ENSLUMG00010021564
 protein coding gene Chr5:38761536-38779395 (+)
SPRET/EiJ ENSMSPG00010035868
 protein coding gene Chr5:40040910-40058478 (+)
WSB/EiJ ENSIUOG00005018420
 protein coding gene Chr5:41596048-41613870 (+)



Homology
more
  • Human Ortholog
    BST1, bone marrow stromal cell antigen 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BST1, bone marrow stromal cell antigen 1
  • Synonyms
    cADPR2, CD157
  • Links
    NCBI Gene ID: 683
    UniProt: Q10588

  • Chr Location
    4p15.32; chr4:15703000-15775614 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show delayed peritoneal B-1 cell development and a rise in CD38low/- B-lineage cells in bone marrow and spleen. The systemic thymus-independent-2 antigen-induced IgG3 and mucosal thymus-dependent antigen-elicited IgA responses are selectively impaired.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    112
  • cDNA Data
    22
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12182 NCBI Gene Model | MGI Sequence Detail 24576 C57BL/6J ±  kb
    transcript NM_009763 RefSeq | MGI Sequence Detail 2336 ZRU/MplStud  
    polypeptide Q64277 UniProt | EBI | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 7
      cDNA 23
      Primer pair 2
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19639, MGD-MRK-27081, MGD-MRK-33039, MGI:104718
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 36
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:344441 Inoue T, et al., Bone marrow stromal cell antigen-1 deficiency protects from acute kidney injury. Am J Physiol Renal Physiol. 2024 Feb 1;326(2):F167-F177
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory