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Ttf1 Gene Detail
Summary
  • Symbol
    Ttf1
  • Name
    transcription termination factor, RNA polymerase I
  • Feature Type
    protein coding gene
  • IDs
    MGI:105044
    NCBI Gene: 22130
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:28950274-28977668 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    881 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105044
 protein coding gene Chr2:28950211-28977668 (+)
129S1/SvImJ ENSMUSG00200052030
 protein coding gene Chr2:25920107-25947502 (+)
A/J ENSMUSG00195045652
 protein coding gene Chr2:26014216-26041615 (+)
AKR/J ENSMUSG00220048927
 protein coding gene Chr2:26131937-26159334 (+)
BALB/cJ ENSMUSG00180049942
 protein coding gene Chr2:26033132-26060530 (+)
C3H/HeJ ENSMUSG00175048977
 protein coding gene Chr2:26002330-26029733 (+)
C57BL/6NJ ENSMUSG00215042808
 protein coding gene Chr2:26061145-26088540 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023363
 protein coding gene Chr2:24931548-24958882 (+)
CAST/EiJ ENSTCUG00005051631
 protein coding gene Chr2:25748584-25775684 (+)
CBA/J ENSMUSG00210016062
 protein coding gene Chr2:26035650-26063046 (+)
DBA/2J ENSMUSG00185050180
 protein coding gene Chr2:25928026-25955422 (+)
FVB/NJ ENSMUSG00205042036
 protein coding gene Chr2:25779896-25807286 (+)
JF1/MsJ ENSUMUG00000055411
 protein coding gene Chr2:25832773-25859516 (+)
LP/J ENSMUSG00230042253
 protein coding gene Chr2:27855963-27883353 (+)
NOD/ShiLtJ ENSMUSG00190036511
 protein coding gene Chr2:26034855-26062250 (+)
NZO/HlLtJ ENSMUSG00225006951
 protein coding gene Chr2:35604930-35632324 (+)
PWK/PhJ ENSLUMG00010051710
 protein coding gene Chr2:25908429-25935014 (+)
SPRET/EiJ ENSMSPG00010040603
 protein coding gene Chr2:26652113-26678703 (+)
WSB/EiJ ENSIUOG00005052330
 protein coding gene Chr2:25886394-25914120 (+)



Homology
more
  • Human Ortholog
    TTF1, transcription termination factor 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTF1, transcription termination factor 1
  • Synonyms
    TTF-1, TTF-I
  • Links
    NCBI Gene ID: 7270
    UniProt: Q15361

  • Chr Location
    9q34.13; chr9:132375548-132406851 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    651
  • Tissues
    54
  • cDNA Data
    56
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026803 Ensembl Gene Model | MGI Sequence Detail 27395 C57BL/6J ±  kb
transcript ENSMUST00000100237 Ensembl | MGI Sequence Detail 4160 Not Applicable  
polypeptide ENSMUSP00000097809 Ensembl | MGI Sequence Detail 859 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001005 SANT/Myb domain
    IPR053078 Transcription termination factor 1
Molecular
Reagents
less
  • All nucleic 58
    Genomic 1
    cDNA 56
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-32083, MGI:2139261
References
more
  • Summaries
    All 68
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 8
  • Earliest
    J:24340 Evers R, et al., Different domains of the murine RNA polymerase I-specific termination factor mTTF-I serve distinct functions in transcription termination. EMBO J. 1995 Mar 15;14(6):1248-56
  • Latest
    J:348286 Zhang Z, et al., Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis. Nat Commun. 2024 May 15;15(1):4108
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory