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Osm Gene Detail
Summary
  • Symbol
    Osm
  • Name
    oncostatin M
  • Synonyms
    OncoM
  • Feature Type
    protein coding gene
  • IDs
    MGI:104749
    NCBI Gene: 18413
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:4186831-4191027 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104749
 protein coding gene Chr11:4186420-4191027 (+)
129S1/SvImJ ENSMUSG00200030349
 protein coding gene Chr11:1140753-1145359 (+)
A/J ENSMUSG00195021939
 protein coding gene Chr11:1048424-1053031 (+)
AKR/J ENSMUSG00220007710
 protein coding gene Chr11:1061114-1065720 (+)
BALB/cJ ENSMUSG00180025717
 protein coding gene Chr11:1070778-1075384 (+)
C3H/HeJ ENSMUSG00175009625
 protein coding gene Chr11:1060534-1065140 (+)
C57BL/6NJ ENSMUSG00215023854
 protein coding gene Chr11:1070946-1075552 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016032
 protein coding gene Chr11:1060807-1065234 (+)
CAST/EiJ ENSTCUG00005034904
 protein coding gene Chr11:1155664-1160297 (+)
CBA/J ENSMUSG00210018173
 protein coding gene Chr11:1060136-1064742 (+)
DBA/2J ENSMUSG00185017791
 protein coding gene Chr11:1157891-1162497 (+)
FVB/NJ ENSMUSG00205027994
 protein coding gene Chr11:1036588-1041194 (+)
JF1/MsJ ENSUMUG00000027504
 protein coding gene Chr11:1319112-1323727 (+)
LP/J ENSMUSG00230034164
 protein coding gene Chr11:2223908-2228514 (+)
NOD/ShiLtJ ENSMUSG00190035282
 protein coding gene Chr11:1048144-1052751 (+)
NZO/HlLtJ ENSMUSG00225025083
 protein coding gene Chr11:4281095-4285702 (+)
PWK/PhJ ENSLUMG00010019076
 protein coding gene Chr11:1057976-1062582 (+)
SPRET/EiJ ENSMSPG00010007335
 protein coding gene Chr11:1134024-1138698 (+)
WSB/EiJ ENSIUOG00005006587
 protein coding gene Chr11:1061885-1066492 (+)



Homology
more
  • Human Ortholog
    OSM, oncostatin M
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OSM, oncostatin M
  • Links
    NCBI Gene ID: 5008
    UniProt: P13725

  • Chr Location
    22q12.2; chr22:30262829-30266851 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice display decreased noxious responses in models of acute thermal, mechanical, chemical, and visceral pain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    648
  • Tissues
    26
  • cDNA Data
    13
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18413 NCBI Gene Model | MGI Sequence Detail 4197 C57BL/6J ±  kb
    transcript NM_001013365 RefSeq | MGI Sequence Detail 1862 ZRU/MplStud  
    polypeptide P53347 UniProt | EBI | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 13
      Primer pair 6
      Antibodies 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-28040
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 14
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:12637 Gough NM, Molecular genetics of leukemia inhibitory factor (LIF) and its receptor. Growth Factors. 1992;7(3):175-9
    • Latest
      J:372600 Rodella A, et al., Oncostatin M is dispensable for the regulation of hematopoietic stem/progenitor cell traffic by neutrophils. iScience. 2025 Jun 20;28(6):112646
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory