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Pkia Gene Detail
Summary
  • Symbol
    Pkia
  • Name
    protein kinase inhibitor, alpha
  • Synonyms
    PKIalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:104747
    NCBI Gene: 18767
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:7431729-7510426 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 1.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3123 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104747
 protein coding gene Chr3:7431695-7510426 (+)
129S1/SvImJ ENSMUSG00200000632
 protein coding gene Chr3:4081373-4160072 (+)
A/J ENSMUSG00195001156
 protein coding gene Chr3:4410042-4489124 (+)
AKR/J ENSMUSG00220016971
 protein coding gene Chr3:4401889-4480966 (+)
BALB/cJ ENSMUSG00180007028
 protein coding gene Chr3:4409512-4488587 (+)
C3H/HeJ ENSMUSG00175004997
 protein coding gene Chr3:4420419-4499478 (+)
C57BL/6NJ ENSMUSG00215005235
 protein coding gene Chr3:4455404-4534108 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024828
 protein coding gene Chr3:3548556-3613448 (+)
CAST/EiJ ENSTCUG00005000192
 protein coding gene Chr3:4468713-4546863 (+)
CBA/J ENSMUSG00210000492
 protein coding gene Chr3:4406062-4485135 (+)
DBA/2J ENSMUSG00185000490
 protein coding gene Chr3:4395097-4477715 (+)
FVB/NJ ENSMUSG00205005854
 protein coding gene Chr3:4223082-4305646 (+)
JF1/MsJ ENSUMUG00000008498
 protein coding gene Chr3:4290907-4371692 (+)
LP/J ENSMUSG00230000065
 protein coding gene Chr3:6355008-6433704 (+)
NOD/ShiLtJ ENSMUSG00190022614
 protein coding gene Chr3:4486240-4568804 (+)
NZO/HlLtJ ENSMUSG00225001474
 protein coding gene Chr3:8894059-8972761 (+)
PWK/PhJ ENSLUMG00010008184
 protein coding gene Chr3:4352294-4433344 (+)
SPRET/EiJ ENSMSPG00010000092
 protein coding gene Chr3:4232301-4309514 (+)
WSB/EiJ ENSIUOG00005000692
 protein coding gene Chr3:4432482-4515094 (+)



Homology
more
  • Human Ortholog
    PKIA, cAMP-dependent protein kinase inhibitor alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PKIA, cAMP-dependent protein kinase inhibitor alpha
  • Synonyms
    PRKACN1
  • Links
    NCBI Gene ID: 5569
    UniProt: P61925

  • Chr Location
    8q21.13; chr8:78516303-78605267 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit decreased basal and isoproterenol-induced phosphoenolpyruvate carboxykinase expression in muscle, but are phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    157
  • cDNA Data
    55
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027499 Ensembl Gene Model | MGI Sequence Detail 78698 C57BL/6J ±  kb
    transcript ENSMUST00000028999 Ensembl | MGI Sequence Detail 3617 Not Applicable  
    polypeptide ENSMUSP00000028999 Ensembl | MGI Sequence Detail 76 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      Genomic 1
      cDNA 55
      Primer pair 3
      Other 2
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28038, MGI:2139695
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 9
    • Earliest
      J:22811 Olsen SR, et al., Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase. J Biol Chem. 1991 Jun 15;266(17):11158-62
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory