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Adam5 Gene Detail
Summary
  • Symbol
    Adam5
  • Name
    a disintegrin and metallopeptidase domain 5
  • Synonyms
    tMDCII
  • Feature Type
    protein coding gene
  • IDs
    MGI:104730
    NCBI Gene: 11499
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:25217109-25314385 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 13.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1555 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104730
 protein coding gene Chr8:25217109-25314385 (-)
129S1/SvImJ ENSMUSG00200021797
 protein coding gene Chr8:20264434-20354512 (-)
A/J ENSMUSG00195004718
 protein coding gene Chr8:20812734-20902818 (-)
AKR/J ENSMUSG00220023230
 protein coding gene Chr8:20436284-20526361 (-)
BALB/cJ ENSMUSG00180005235
 protein coding gene Chr8:20337359-20427446 (-)
C3H/HeJ ENSMUSG00175006372
 protein coding gene Chr8:20400138-20490214 (-)
C57BL/6NJ ENSMUSG00215005645
 protein coding gene Chr8:20300780-20398068 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030916
 protein coding gene Chr8:19243726-19313420 (-)
CAST/EiJ ENSTCUG00005023382
 protein coding gene Chr8:20612231-20700147 (-)
CBA/J ENSMUSG00210013557
 protein coding gene Chr8:20336728-20426812 (-)
DBA/2J ENSMUSG00185035781
 protein coding gene Chr8:26137380-26227452 (-)
FVB/NJ ENSMUSG00205024180
 protein coding gene Chr8:19834911-19924988 (-)
JF1/MsJ ENSUMUG00000012179
 protein coding gene Chr8:28024221-28110043 (-)
LP/J ENSMUSG00230010306
 protein coding gene Chr8:29896938-29987003 (-)
NOD/ShiLtJ ENSMUSG00190004267
 protein coding gene Chr8:20370199-20460266 (-)
NZO/HlLtJ ENSMUSG00225021219
 protein coding gene Chr8:33518318-33608386 (-)
PWK/PhJ ENSLUMG00010025295
 protein coding gene Chr8:20385121-20470989 (-)
SPRET/EiJ ENSMSPG00010016390
 protein coding gene Chr8:20656333-20736236 (-)
WSB/EiJ ENSIUOG00005009245
 protein coding gene Chr8:21082690-21169529 (-)



Homology
more
  • Human Ortholog
    ADAM5, ADAM metallopeptidase domain 5 (pseudogene)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM5, ADAM metallopeptidase domain 5 (pseudogene)
  • Synonyms
    ADAM5P, TMDCII
  • Links
    NCBI Gene ID: 255926
    UniProt: Q6NVV9

  • Chr Location
    8p11.22; chr8:39314591-39417378 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show severe male subfertility, impaired sperm binding to the zona pellucida and to extracellular matrix components, and impaired uterotubal junction transit, but no alterations in spermatogenesis, sperm morphology or sperm motility. Female fertility is normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    22
  • cDNA Data
    25
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11499 NCBI Gene Model | MGI Sequence Detail 97277 C57BL/6J ±  kb
    transcript NM_001272058 RefSeq | MGI Sequence Detail 2956 ZRU/MplStud  
    polypeptide Q3TTE0 UniProt | EBI | MGI Sequence Detail 751 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 25
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-27093
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:17855 Ballock RT, et al., Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. J Cell Physiol. 1994 May;159(2):340-6
    • Latest
      J:385037 Mashiko D, et al., ADAM5 is required for sperm-zona pellucida binding and sperm oviduct migration. Biol Reprod. 2026 Mar 16;114(3):1091-1100
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory