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Tcf15 Gene Detail
Summary
  • Symbol
    Tcf15
  • Name
    transcription factor 15
  • Synonyms
    bHLH-EC2, Meso1, paraxis
  • Feature Type
    protein coding gene
  • IDs
    MGI:104664
    NCBI Gene: 21407
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:151985481-151991017 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104664
 protein coding gene Chr2:151984973-151991017 (+)
129S1/SvImJ ENSMUSG00200028986
 protein coding gene Chr2:148890583-148896118 (+)
A/J ENSMUSG00195021466
 protein coding gene Chr2:149170396-149175932 (+)
AKR/J ENSMUSG00220042643
 protein coding gene Chr2:148493917-148499453 (+)
BALB/cJ ENSMUSG00180042689
 protein coding gene Chr2:148655425-148660962 (+)
C3H/HeJ ENSMUSG00175037504
 protein coding gene Chr2:149401654-149407190 (+)
C57BL/6NJ ENSMUSG00215018351
 protein coding gene Chr2:148828636-148834172 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024447
 protein coding gene Chr2:144030870-144036423 (+)
CAST/EiJ ENSTCUG00005041618
 protein coding gene Chr2:147758102-147763637 (+)
CBA/J ENSMUSG00210042830
 protein coding gene Chr2:149338158-149343694 (+)
DBA/2J ENSMUSG00185042700
 protein coding gene Chr2:148988652-148994188 (+)
FVB/NJ ENSMUSG00205021094
 protein coding gene Chr2:148085373-148090909 (+)
JF1/MsJ ENSUMUG00000044955
 protein coding gene Chr2:148674489-148680033 (+)
LP/J ENSMUSG00230033342
 protein coding gene Chr2:150643016-150648551 (+)
NOD/ShiLtJ ENSMUSG00190030711
 protein coding gene Chr2:148774022-148779566 (+)
NZO/HlLtJ ENSMUSG00225004404
 protein coding gene Chr2:158676787-158682323 (+)
PWK/PhJ ENSLUMG00010035050
 protein coding gene Chr2:148644343-148649888 (+)
SPRET/EiJ ENSMSPG00010025715
 protein coding gene Chr2:151369947-151375508 (+)
WSB/EiJ ENSIUOG00005039716
 protein coding gene Chr2:148505949-148511484 (+)



Homology
more
  • Human Ortholog
    TCF15, transcription factor 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF15, transcription factor 15
  • Synonyms
    bHLHa40, EC2, PARAXIS
  • Links
    NCBI Gene ID: 6939
    UniProt: Q12870

  • Chr Location
    20p13; chr20:604257-610309 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
In homozygotes for a targeted null mutation, cells of the paraxial mesoderm fail to form epithelia resulting in disrupted somites, patterning defects of the axial skeleton, peripheral nerves, and skeletal muscles, and perinatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    78
  • cDNA Data
    18
  • Literature Summary
    59
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068079 Ensembl Gene Model | MGI Sequence Detail 5537 C57BL/6J ±  kb
    transcript ENSMUST00000089112 Ensembl | MGI Sequence Detail 980 Not Applicable  
    polypeptide ENSMUSP00000086511 Ensembl | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 1
      cDNA 20
      Primer pair 5
      Other 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26104
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 59
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:388827 Chen Y, et al., Gastrula-Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross-Talk with TGF-beta Signaling Pathway. Adv Sci (Weinh). 2025 Sep;12(36):e00895
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory