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Tle1 Gene Detail
Summary
  • Symbol
    Tle1
  • Name
    transducin-like enhancer of split 1
  • Synonyms
    C230057C06Rik, Estm14, Grg1, Tle4l
  • Feature Type
    protein coding gene
  • IDs
    MGI:104636
    NCBI Gene: 21885
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:72036042-72119130 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 36.06 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1979 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104636
 protein coding gene Chr4:72028182-72124575 (-)
129S1/SvImJ ENSMUSG00200000454
 protein coding gene Chr4:67028562-67112489 (-)
A/J ENSMUSG00195000815
 protein coding gene Chr4:67599505-67683283 (-)
AKR/J ENSMUSG00220018553
 protein coding gene Chr4:67309779-67393572 (-)
BALB/cJ ENSMUSG00180000803
 protein coding gene Chr4:66574832-66658614 (-)
C3H/HeJ ENSMUSG00175006493
 protein coding gene Chr4:67411480-67495264 (-)
C57BL/6NJ ENSMUSG00215000816
 protein coding gene Chr4:67450051-67533835 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026108
 protein coding gene Chr4:65522850-65606410 (-)
CAST/EiJ ENSTCUG00005014487
 protein coding gene Chr4:67156468-67241627 (-)
CBA/J ENSMUSG00210000464
 protein coding gene Chr4:67098685-67182477 (-)
DBA/2J ENSMUSG00185015296
 protein coding gene Chr4:67524728-67608542 (-)
FVB/NJ ENSMUSG00205000999
 protein coding gene Chr4:65816710-65900491 (-)
JF1/MsJ ENSUMUG00000000551
 protein coding gene Chr4:68158271-68242219 (-)
LP/J ENSMUSG00230010336
 protein coding gene Chr4:71013527-71097470 (-)
NOD/ShiLtJ ENSMUSG00190009111
 protein coding gene Chr4:66495170-66579005 (-)
NZO/HlLtJ ENSMUSG00225027934
 protein coding gene Chr4:76056060-76139838 (-)
PWK/PhJ ENSLUMG00010009738
 protein coding gene Chr4:65914769-65998707 (-)
SPRET/EiJ ENSMSPG00010004957
 protein coding gene Chr4:67256283-67340433 (-)
WSB/EiJ ENSIUOG00005000336
 protein coding gene Chr4:66905759-66994815 (-)



Homology
more
  • Human Ortholog
    TLE1, TLE family member 1, transcriptional corepressor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLE1, TLE family member 1, transcriptional corepressor
  • Synonyms
    ESG, ESG1, GRG1, TLE-1
  • Links
    NCBI Gene ID: 7088
    UniProt: Q04724

  • Chr Location
    9q21.32; chr9:81582313-81689681 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    931
  • Tissues
    210
  • cDNA Data
    25
  • Literature Summary
    45
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008305 Ensembl Gene Model | MGI Sequence Detail 83089 C57BL/6J ±  kb
    transcript ENSMUST00000030095 Ensembl | MGI Sequence Detail 2569 Not Applicable  
    polypeptide ENSMUSP00000030095 Ensembl | MGI Sequence Detail 780 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 28
      Primer pair 5
      Other 6
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-26073, MGI:2178299, MGI:2444832
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 45
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:29516 Mallo M, et al., Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Dev Dyn. 1995 Nov;204(3):338-47
    • Latest
      J:369798 Anirudhan J, et al., Novel Insights into Emx2 and Dmrta2 Cooperation during Cortex Development and Evidence for Dmrta2 Function in the Choroid Plexus. J Neurosci. 2025 Jul 2;45(27)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory