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Gbp2 Gene Detail
Summary
  • Symbol
    Gbp2
  • Name
    guanylate binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102772
    NCBI Gene: 14469
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:142326424-142343769 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    609 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102772
 protein coding gene Chr3:142326363-142343769 (+)
129S1/SvImJ ENSMUSG00200002389
 protein coding gene Chr3:139140617-139158027 (+)
A/J ENSMUSG00195003971
 protein coding gene Chr3:139317037-139334452 (+)
AKR/J ENSMUSG00220003169
 protein coding gene Chr3:137710862-137728273 (+)
BALB/cJ ENSMUSG00180011447
 protein coding gene Chr3:139187671-139205076 (+)
C3H/HeJ ENSMUSG00175019081
 protein coding gene Chr3:138771153-138788568 (+)
C57BL/6NJ ENSMUSG00215022831
 protein coding gene Chr3:139509241-139526645 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025696
 protein coding gene Chr3:135889009-135907579 (+)
CAST/EiJ ENSTCUG00005027841
 protein coding gene Chr3:139926475-139943754 (+)
CBA/J ENSMUSG00210029435
 protein coding gene Chr3:139456180-139473610 (+)
DBA/2J ENSMUSG00185003238
 protein coding gene Chr3:140037431-140054842 (+)
FVB/NJ ENSMUSG00205022844
 protein coding gene Chr3:138332796-138350207 (+)
JF1/MsJ ENSUMUG00000002745
 protein coding gene Chr3:138856560-138873969 (+)
LP/J ENSMUSG00230003056
 protein coding gene Chr3:141953367-141970777 (+)
NOD/ShiLtJ ENSMUSG00190004423
 protein coding gene Chr3:140404668-140422079 (+)
NZO/HlLtJ ENSMUSG00225002219
 protein coding gene Chr3:144454661-144472072 (+)
PWK/PhJ ENSLUMG00010020554
 protein coding gene Chr3:138756811-138774238 (+)
SPRET/EiJ ENSMSPG00010013297
 protein coding gene Chr3:139998075-140021890 (+)
WSB/EiJ ENSIUOG00005018268
 protein coding gene Chr3:139562501-139579915 (+)



Homology
more
  • Human Ortholog
    GBP1, guanylate binding protein 1
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GBP1, guanylate binding protein 1
  • Synonyms
    hGBP1
  • Links
    NCBI Gene ID: 2633
    UniProt: P32455

  • Chr Location
    1p22.2; chr1:89051505-89072769 (-)  GRCh38
  • Human Ortholog
    GBP2, guanylate binding protein 2
  • Links
    NCBI Gene ID: 2634
    UniProt: P32456

  • Chr Location
    1p22.2; chr1:89106132-89150456 (-)  GRCh38
  • Human Ortholog
    GBP3, guanylate binding protein 3
  • Links
    NCBI Gene ID: 2635
    UniProt: Q9H0R5

  • Chr Location
    1p22.2; chr1:89006666-89022894 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to increased susceptibility to chronic Toxoplasma gondii infection, characterized by an increased parasite burden in the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    695
  • Tissues
    98
  • cDNA Data
    119
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14469 NCBI Gene Model | MGI Sequence Detail 17346 C57BL/6J ±  kb
    transcript NM_010260 RefSeq | MGI Sequence Detail 2471 ZRU/MplStud  
    polypeptide Q9Z0E6 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
      3.6.5.-
    • InterPro Domains
      IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
      IPR003191 Guanylate-binding protein/Atlastin, C-terminal
      IPR037684 Guanylate-binding protein, C-terminal
      IPR036543 Guanylate-binding protein, C-terminal domain superfamily
      IPR015894 Guanylate-binding protein, N-terminal
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q9Z0E6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 124
      Genomic 2
      cDNA 119
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19679
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 19
      Phenotypes 44
    • Earliest
      J:37849 Cheng YS, et al., Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP. Mol Cell Biol. 1991 Sep;11(9):4717-25
    • Latest
      J:382922 Pizzuto M, et al., Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11. EMBO J. 2025 Aug;44(16):4419-4442
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory