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Lilrb4a Gene Detail
Summary
  • Symbol
    Lilrb4a
  • Name
    leukocyte immunoglobulin-like receptor, subfamily B, member 4A
  • Synonyms
    CD85K, Gp49b, HM18, ILT3, Lilrb4
  • Feature Type
    protein coding gene
  • IDs
    MGI:102701
    NCBI Gene: 14728
  • Alliance
    genome feature page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:51367052-51372707 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 25.50 cM, cytoband B4
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    416 from dbSNP Build 142
  • Strain Annotations
    27
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102701
 protein coding gene Chr10:51366999-51372709 (+)
129S1/SvImJ ENSMUSGG00200054770
 protein coding gene Chr10:48256583-48257283 (+)
129S1/SvImJ ENSMUSG00200007189
 protein coding gene Chr10:48257526-48259673 (+)
A/J ENSMUSG00195002757
 protein coding gene Chr10:48532181-48534328 (+)
A/J ENSMUSGG00195055480
 protein coding gene Chr10:48531238-48531938 (+)
AKR/J ENSMUSGG00220054791
 protein coding gene Chr10:48211316-48212016 (+)
AKR/J ENSMUSG00220005836
 protein coding gene Chr10:48212259-48214406 (+)
BALB/cJ ENSMUSGG00180055110
 protein coding gene Chr10:48660925-48661626 (+)
BALB/cJ ENSMUSG00180011713
 protein coding gene Chr10:48661869-48664016 (+)
C3H/HeJ ENSMUSG00175009957
 protein coding gene Chr10:48403055-48405202 (+)
C3H/HeJ ENSMUSGG00175054796
 protein coding gene Chr10:48402112-48402812 (+)
C57BL/6NJ ENSMUSGG00215055579
 protein coding gene Chr10:48166014-48166714 (+)
C57BL/6NJ ENSMUSG00215002026
 protein coding gene Chr10:48166957-48169104 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055014
 protein coding gene Chr10:48305329-48306029 (+)
CBA/J ENSMUSG00210007914
 protein coding gene Chr10:48306272-48308419 (+)
DBA/2J ENSMUSG00185003164
 protein coding gene Chr10:48462412-48464559 (+)
DBA/2J ENSMUSGG00185057759
 protein coding gene Chr10:48461469-48462169 (+)
FVB/NJ ENSMUSGG00205054504
 protein coding gene Chr10:48380892-48381592 (+)
FVB/NJ ENSMUSG00205004711
 protein coding gene Chr10:48381835-48383982 (+)
JF1/MsJ ENSUMUG00000018852
 protein coding gene Chr10:48150056-48155708 (+)
LP/J ENSMUSGG00230055585
 protein coding gene Chr10:50263057-50263757 (+)
LP/J ENSMUSG00230021273
 protein coding gene Chr10:50264000-50266147 (+)
NOD/ShiLtJ ENSMUSG00190005490
 protein coding gene Chr10:48626737-48628884 (+)
NOD/ShiLtJ ENSMUSGG00190054845
 protein coding gene Chr10:48625794-48626494 (+)
NZO/HlLtJ ENSMUSGG00225055509
 protein coding gene Chr10:54543952-54544652 (+)
NZO/HlLtJ ENSMUSG00225022153
 protein coding gene Chr10:54544895-54547042 (+)
PWK/PhJ ENSLUMG00010004454
 protein coding gene Chr10:48286469-48292057 (+)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit increased sensitivity to IgE-dependent passive cutaneous anaphylaxis and a reduced threshold for antigen challenge in active cutaneous anaphylaxis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    616
  • Tissues
    19
  • cDNA Data
    31
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000112148 Ensembl Gene Model | MGI Sequence Detail 5656 C57BL/6J ±  kb
    transcript ENSMUST00000078778 Ensembl | MGI Sequence Detail 1381 Not Applicable  
    polypeptide ENSMUSP00000077833 Ensembl | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 4
      cDNA 33

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19605
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 2
      Gene Ontology 19
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:371635 Sultan H, et al., Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy. Nature. 2024 Aug;632(8023):182-191
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory