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Sfswap Gene Detail
Summary
  • Symbol
    Sfswap
  • Name
    splicing factor SWAP
  • Synonyms
    1190005N23Rik, 6330437E22Rik, Sfrs8
  • Feature Type
    protein coding gene
  • IDs
    MGI:101760
    NCBI Gene: 231769
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:129578286-129648448 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 68.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1688 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101760
 protein coding gene Chr5:129578285-129648448 (+)
129S1/SvImJ ENSMUSG00200041865
 protein coding gene Chr5:123324117-123394259 (+)
A/J ENSMUSG00195047400
 protein coding gene Chr5:122853482-122923699 (+)
AKR/J ENSMUSG00220049515
 protein coding gene Chr5:122333562-122403728 (+)
BALB/cJ ENSMUSG00180034776
 protein coding gene Chr5:122960899-123031122 (+)
C3H/HeJ ENSMUSG00175034229
 protein coding gene Chr5:124933257-125003420 (+)
C57BL/6NJ ENSMUSG00215048714
 protein coding gene Chr5:122995313-123065482 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027780
 protein coding gene Chr5:122371450-122443268 (+)
CAST/EiJ ENSTCUG00005008695
 protein coding gene Chr5:122201521-122271714 (+)
CBA/J ENSMUSG00210006129
 protein coding gene Chr5:123683935-123754097 (+)
DBA/2J ENSMUSG00185007479
 protein coding gene Chr5:126735848-126806019 (+)
FVB/NJ ENSMUSG00205027324
 protein coding gene Chr5:122618156-122688309 (+)
JF1/MsJ ENSUMUG00000048746
 protein coding gene Chr5:129622136-129691157 (+)
LP/J ENSMUSG00230044298
 protein coding gene Chr5:130840033-130910175 (+)
NOD/ShiLtJ ENSMUSG00190026678
 protein coding gene Chr5:122639736-122709861 (+)
NZO/HlLtJ ENSMUSG00225014142
 protein coding gene Chr5:138534445-138604642 (+)
PWK/PhJ ENSLUMG00010016509
 protein coding gene Chr5:121497967-121567027 (+)
SPRET/EiJ ENSMSPG00010026774
 protein coding gene Chr5:124837477-124907033 (+)
WSB/EiJ ENSIUOG00005032387
 protein coding gene Chr5:125312615-125382849 (+)



Homology
more
  • Human Ortholog
    SFSWAP, splicing factor SWAP
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SFSWAP, splicing factor SWAP
  • Synonyms
    SFRS8, SWAP
  • Links
    NCBI Gene ID: 6433
    UniProt: Q12872

  • Chr Location
    12q24.33; chr12:131711081-131799738 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit a wobbly phenotype with inner ear defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    642
  • Tissues
    31
  • cDNA Data
    127
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231769 NCBI Gene Model | MGI Sequence Detail 70163 C57BL/6J ±  kb
    transcript NM_001378915 RefSeq | MGI Sequence Detail 3447 C57BL/6  
    polypeptide Q3USH5 UniProt | EBI | MGI Sequence Detail 945 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      cDNA 127

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-18566, MGI:1916187, MGI:2140818, MGI:2141174, MGI:2443987
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:363654 Wang J, et al., Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice. J Neurosci. 2025 Feb 26;45(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory