Caution: These are Prototype Reports for Evaluation Purposes Only!
MGD Full QTL Report
J# 37769 Teale et al. 1995
Bibliographic information for J37769
Phenotype Information
Progeny Population Information
Methods
QTL Data
Candidate Genes
General Comments
- Phenotype Class: Resistance/Susceptibility
- Phenotype Mode: Induced
- Induced by: IP inoculation of Trypanosome congolense clone IL1180 at 10^4 bloodstream form parasites
- Phenotype Name: Resistance to trypanosomiasis
- Phenotype Trait 1: Survival
- Phenotype Assessment: qualitative
- Alternative Keywords: NULL
- Strain/Progenitor Information:
- Strain 1:C57BL/6J
- Strain 1 Comment: resistant trypanosomiasis
- Strain 2: C57BL/10
- Strain 2 Comment: resistant to trypanosomiasis
- Strain 3: BALB/c
- Strain 3 Comment: relatively susceptible to trypanosomiasis
- Strain 2:A/J
- Strain 4 Comment: very susceptible to trypanosomiasis
- Phenotype Comments:NULL
QTL Experiment # 1
- Progeny Generation Used for QTL Experiment: F2
- Progeny Population Name: NULL
- # Animals Evaluated: 399
- Female Parent:(C57BL/6J X BALB/c)F1
- Male Parent: (C57BL/6J X BALB/c)F1
- Cross Type: intercross
- Another cross for this progeny population?: No
- Comments:
- 1) Two QTL experiments performed on two different progeny
populations.
QTL Experiment # 2
- Progeny Generation Used for QTL Experiment: F2
- Progeny Population Name: NULL
- # Animals Evaluated: 860
- Female Parent:(C57BL/6J X A/J)F1
- Male Parent: (C57BL/6J X A/J)F1
- Cross Type: intercross
- Another cross for this progeny population?: No
- Comments:
- 1) Two QTL experiments performed on two different progeny
populations.
- Chromosomes Used in Marker Map Construction:All
- Marker Map Methods:
- Number of Markers in Analysis:NULL
- Intermarker Distance: NULL
- Comments on Marker Map:NULL
- QTL Detection Method:LOD
- Significance Threshold for QTL Detection: NULL
- Significance Threshold Comment:NULL
- QTL Estimation Method: interval mapping
- Comments on QTL Estimation Model Used: NULL
- QTL Mapping Software
- MapMaker/EXP
- MapMaker/QTL
QTL Experiment # 1 : (C57BL/6J X BALB/c)F2
QTL Symbol: Tir-1
- QTL Detection Method: LOD
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| Tir-1
| NULL
| > 10
| NULL
| 10
|
- QTL Estimation:
- Chromosome: 17
- Location: Peak LOD score at 7 cM and 26 cM
- % Phenotypic Variation Accounted For: NULL
- Confidence Interval for QTL Estimation: NULL
- Comments:NULL
QTL Information for J37769
QTL Experiment # 1 : (C57BL/6J X BALB/c)F2
QTL Symbol: Tir-2
- QTL Detection Method:LOD
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| Tir-2
| NULL
| > 4
| NULL
| 5
|
- QTL Estimation:
- Chromosome: 5
- Location: Peak LOD score at 30 cM
- % Phenotypic Variation Accounted For: NULL
- Confidence Interval for QTL Estimation: NULL
- Comments:NULL
QTL Information for J37769
QTL Experiment # 1 : (C57BL/6J X BALB/c)F2
QTL Symbol: Tir-3
- QTL Detection Method:LOD
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| Tir-3
| NULL
| > 5
| NULL
| 1
|
- QTL Estimation:
- Chromosome: 1
- Location: Peak LOD score at 87 cM
- % Phenotypic Variation Accounted For: NULL
- Confidence Interval for QTL Estimation: NULL
- Comments:NULL
QTL Information for J37769
QTL Experiment # 2 : (C57BL/6J X A/J)F2
QTL Symbol: Tir-1
- QTL Detection Method: LOD
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| Tir-1
| NULL
| > 3
| NULL
| 17
|
- QTL Estimation:
- Chromosome: 17
- Location: Peak LOD score at 7 cM and 26 cM
- % Phenotypic Variation Accounted For: NULL
- Confidence Interval for QTL Estimation: NULL
- Comments:NULL
QTL Experiment # 2 : (C57BL/6J X A/J)F2
QTL Symbol: Tir-2
- QTL Detection Method: LOD
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| Tir-2
| NULL
| > 9
| NULL
| 5
|
- QTL Estimation:
- Chromosome: 5
- Location: Peak LOD score at 30 cM
- % Phenotypic Variation Accounted For: NULL
- Confidence Interval for QTL Estimation: NULL
- Comments:NULL
| QTL Symbol(s)
| Candidate Gene Symbol |
Chromosome |
Gene Name |
| Tir-1
| Tnf
| 17
| tumor necrosis factor
|
- 1) Tir-2 acts in a dominant fashion
- 2) Tir-3 acts in an additive fashion
- 3) Tir-1 at the distal half of 17 acts in a recessive manner; Tir-1 in
the proximal half of 17 acts in an additive fashion.
- 4) Tir-3 on chromosome 1 not detected in (C57BL/6J X A/J)F2
- 5) The effects of the chromosome 17 QTLs was determined by phenotyping
two F3 populations
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