Caution: These are Prototype Reports for Internal Evaluation Purposes Only!

MGD Full QTL Report

J# 30687 Miner et al. 1995

Phenotype Class: Drug Response
Phenotype Mode: Induced
- Induced by: IP injection with cocaine 10 mg/kg
Phenotype Name: Psychomotor stimulant effects
- Phenotype Trait 1: baseline locomotor activity
- Phenotype Assessment: quantitative
- Phenotype Trait 2: uncorrected locomotor activity
- Phenotype Assessment: quantitative
- Phenotype Trait 3: corrected locomotor activity
- Phenotype Assessment: quantitative
Alternative Keywords: cocaine, psychostimulant
Strain/Progenitor Information:
- Strain 1:C57BL/6J
- Strain 1 Comment: locomotor activity relatively sensitive to cocaine
- Strain 2:DBA/2J
- Strain 2 Comment: locomotor activity relatively insensitive to cocaine
Phenotype Comments:NULL
- 1) phenotype evaluated as distance (in cm) traveled in 30 minutes
- 2) saline injections given as control

Chromosomes Included in Marker Map Coverage:All
Marker Map Methods:
- panel of BXD markers
Number of Markers in Analysis: 2000
Intermarker Distance: NULL
Comments on Marker Map:NULL
QTL Detection Method:Pearson's r correlation
Significance Threshold for QTL Detection: P < 0.01
- Significance Threshold Comment:NULL
QTL Estimation Method: multiple regression
Comments on QTL Estimation Model Used: NULL
QTL Mapping Software: NULL

Table of Linked Markers:

QTL Symbol	Linked Marker Symbol	Association Score	P Value	Chromosome
Unnamed	Xmmv23	0.830	NULL	4
Unnamed	D9Ncvs41	0.823	NULL	9
Unnamed	D9Ncvs55	0.896	NULL	9
Unnamed	D9Mit12	0.823	NULL	9
Unnamed	Rbp1	0.831	NULL	9
Unnamed	D9Ncvs48	0.823	NULL	9
Unnamed	Xmmv23	0.830	NULL	4
Unnamed	Ltw3	0.830	NULL	9
Unnamed	D9Ncvs17	0.799	NULL	9
Unnamed	Xmmv23	0.830	NULL	4
Unnamed	D9Ncvs43	0.837	NULL	9
Unnamed	D9Byu4	0.837	NULL	9
Unnamed	Xmmv23	0.830	NULL	4
Unnamed	Xmmv23	0.830	NULL	4
Unnamed	Ras122	0.837	NULL	9
Unnamed	Tpmt	-0.786	NULL	13
Unnamed	D17Tu50	0.752	NULL	17
Unnamed	D17Tu30	0.752	NULL	17
Unnamed	D17Tu36	0.821	NULL	17
Unnamed	Rbp4	0.815	NULL	19

QTL Estimation:
- Chromosome: NULL
- Location:NULL
- % Phenotypic Variation Accounted For: 80%
- Confidence Interval for QTL Estimation: NULL
Comments:NULL

Table of Linked Markers:

QTL Symbol	Linked Marker Symbol	Association Score	P Value	Chromosome
Unnamed	D3Mit19	0.775	NULL	3
Unnamed	Xmmv23	0.850	NULL	4
Unnamed	Mpmv7	-0.858	NULL	5
Unnamed	Pmv5	-0.858	NULL	5
Unnamed	D5Nds1	-0.845	NULL	5
Unnamed	D8Ncvs31	-0.794	NULL	8
Unnamed	Defcr	-0.794	NULL	8
Unnamed	D9Ncvs41	0.750	NULL	9
Unnamed	D9Mit12	0.750	NULL	9
Unnamed	Rbp1	0.780	NULL	9
Unnamed	Rbp2	0.750	NULL	9
Unnamed	D9Ncvs48	0.750	NULL	9
Unnamed	D9Ncvs42	0.861	NULL	9
Unnamed	D16Mit4	-0.775	NULL	16
Unnamed	D16Bir1	-0.813	NULL	16

QTL Estimation:
- Chromosome: NULL
- Location:NULL
- % Phenotypic Variation Accounted For: 56%
- Confidence Interval for QTL Estimation: NULL
Comments:NULL

Table of Linked Markers:

QTL Symbol	Linked Marker Symbol	Association Score	P Value	Chromosome
Unnamed	D3Byu5	0.760	NULL	3
Unnamed	D3Ncvs30	0.833	NULL	3
Unnamed	D3Ncvs31	0.833	3
Unnamed	D3Ncvs32	0.833	NULL	3
Unnamed	Amy1	0.833	NULL	3
Unnamed	Amy2	0.833	NULL	3
Unnamed	D3Nds5	0.833	NULL	3
Unnamed	D3Ncvs45	0.818	NULL	3
Unnamed	D3Ncvs44	0.833	NULL	3
Unnamed	D3J3	0.833	NULL	3
Unnamed	Fabp1	0.833	NULL	3
Unnamed	D3Ncvs33	0.833	NULL	3
Unnamed	D3Ncvs8	0.819	NULL	3
Unnamed	Adh1ps	0.827	NULL	3
Unnamed	Oatrs2	0.729	NULL	3
Unnamed	Pmv39	0.729	NULL	3
Unnamed	D3Mit19	0.609	NULL	3
Unnamed	Nhe1	0.786	NULL	4
Unnamed	Tpi1	0.810	NULL	6
Unnamed	D7Ncvs49	0.753	NULL	7
Unnamed	D10Mit11	-0.761	NULL	10
Unnamed	D10Mit10	-0.761	NULL	10
Unnamed	D10Mit14	-0.766	NULL	10
Unnamed	Gln3-4	-0.714	NULL	17
Unnamed	Gln3-7	-0.714	NULL	17
Unnamed	D17Lh173	-0.714	NULL	17
Unnamed	Ms15-3	-0.714	NULL	17
Unnamed	D17Mit11	-0.778	NULL	17
Unnamed	D17Tu16	-0.764	NULL	17
Unnamed	Tpx1	-0.764	NULL	17
Unnamed	D17Lh116	-0.764	NULL	17
Unnamed	D17Lh154	-0.764	NULL	17
Unnamed	D17Leh23	-0.764	NULL	17
Unnamed	Iapls1-13	-0.764	NULL	17
Unnamed	Tcte1	-0.764	NULL	17
Unnamed	D17Ncvs7	-0.764	NULL	17
Unnamed	D17Ncvs32	-0.764	NULL	17
Unnamed	Upg1	-0.764	NULL	17
Unnamed	D17Byu2	-0.764	NULL	17
Unnamed	D17Mit10	-0.761	NULL	17
Unnamed	D17Mit6	-0.761	NULL	17
Unnamed	D17Ncvs7	-0.764	NULL	17
Unnamed	D17Mit17	-0.761	NULL	17
Unnamed	Ckb-rs2	-0.764	NULL	17
Unnamed	D18Mit15	0.800	NULL	18

QTL Estimation:
- Chromosome: NULL
- Location:NULL
- % Phenotypic Variation Accounted For: 85%
- Confidence Interval for QTL Estimation: NULL
Comments:NULL

QTL Symbol(s)	Candidate Gene Symbol	Chromosome	Gene Name
Unnamed	Grik3	4	glutamate receptor, iosotropic, kainate 3
Unnamed	Oprd1	4	opioid receptor, delta 1
Unnamed	ADH	4	alcohol dehydrogenase
Unnamed	Drd5	5	dopamine receptor 5
Unnamed	Drd2	9	dopamine receptor 2
Unnamed	Acra3	9	acetylcholine receptor alpha 3 neural
Unnamed	Acra5	9	acetylcholine receptor alpha 5 neural
Unnamed	Htr1b	9	5-hydroxytryptamine (serotonin) receptor 1B
Unnamed	Cck	9	cholecystokinin
Unnamed	Obcam	9	opioid binding cell adhesion molecule
Unnamed	Dat1	13	dopamine transporter 1

1) Chromosomal regions on 4,5, and 9 have significant associations with baseline and uncorrected cocaine-stimulated locomotor activity.
2) Largest correlations are on chromosome 9 and are consistent with other drug response loci found in this region. 3) Authors suggest that the corrected trait scores may be a better indicator of cocaine response than uncorrected scores because of the low correlation between baseline locomotor activity measurements and corrected activity measurements.