Caution: These are Prototype Reports for Evaluation Purposes Only!
MGD Full QTL Report
J# 20482 Phillips et al., 1994
Bibliographic information for J20482
Phenotype Information
Progeny Population Information
Methods
QTL Data
Candidate Genes
General Comments
- Phenotype Class: Behavior
- Phenotype Mode: Hereditary
- Phenotype Name: Alcohol acceptance
- Phenotype Trait 1: 3% unsweetened ethanol (g/kg/day)
- Phenotype Assessment: quantitative
- Phenotype Trait 2: 10% unsweetened ethanol(g/kg/day)
- Phenotype Assessment: quantitative
- Phenotype Trait 1: 3% ethanol in 0.2% saccharin (g/kg/day)
- Phenotype Assessment: quantitative
- Phenotype Trait 1: 10% ethanol in 0.2% saccharin(g/kg/day)
- Phenotype Assessment: quantitative
- Phenotype Trait 1: 0.2% saccharin (g/kg/day)
- Phenotype Assessment: quantitative
- Alternative Keywords: ethanol, sacchrin, withdrawal, drinking behavior
- Strain/Progenitor Information:
- Strain 1:C57BL/6J
- Strain 1 Comment: alcohol acceptance
- Strain 2: DBA/2J
- Strain 2 Comment: alcohol avoidance
- Phenotype Comments:
- 1) free choice alcohol consumption methods used
- Progeny Generation Used for QTL Experiment:BXD RI
- # Strains Evaluated: 19
- # Animals Evaluated: 279
- Comments:
- 1) only females evaluated for the traits
- Chromosomes Included in Marker Map Coverage: ALL
- Marker Map Methods:
- Number of Markers in Analysis: 163
- Intermarker Distance: NULL
- Comments on Marker Map: NULL
- QTL Detection Method: Chi-square Contingency tests
- Significance Threshold for QTL Detection: P < 0.01 and P < 0.05
- Significance Threshold Comment: NULL
- QTL Estimation Method: multiple regression
- Comments on QTL Estimation Model Used: NULL
- QTL Mapping Software:NULL
- Comments:
- 1) Traits correlated at P <0.05 value were accepted as significant if
the marker also had a signficant association with another drinking
phenotype at the P <0.01 level.
QTL Symbol: Unnamed
- QTL Detection Method: Correlation
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| Unnamed
| D1Mit1
| 0.69
| NULL
| 1
|
| Unnamed
| D1Mit5
| 0.68
| NULL
| 1
|
| Unnamed
| Myif
| 0.64
| NULL
| 1
|
| Unnamed
| Lck
| -0.49
| NULL
| 4
|
| Unnamed
| D7Rp2
| 0.58
| NULL
| 7
|
| Unnamed
| Rasl4
| -0.49
| NULL
| 7
|
| Unnamed
| D8Bir2
| -0.57
| NULL
| 8
|
| Unnamed
| D17Tu8
| -0.61
| NULL
| 13?
|
- QTL Estimation
- Chromosome: 1,4,7,8,13
- Location: NULL
- % Phenotypic Variation Accounted For: 82%
- Confidence Interval for QTL Estimation: NULL
- Comments:NULL
QTL Symbol: Unnamed
- QTL Detection Method: Correlation
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| Unnamed
| D2Mc2
| -0.68
| NULL
| 2
|
| Unnamed
| Pmv-26
| -0.52
| NULL
| 3
|
| Unnamed
| Lck
| -0.65
| NULL
| 4
|
| Unnamed
| Nhe-1
| -0.65
| NULL
| 4
|
| Unnamed
| D7Rp2
| 0.72
| NULL
| 7
|
| Unnamed
| Rasl4
| -0.58
| NULL
| 7
|
| Unnamed
| Drd2
| -0.56
| NULL
| 9
|
| Unnamed
| Ncam
| -0.58
| NULL
| 9
|
| Unnamed
| Xmmv-2
| -0.58
| NULL
| 9
|
- QTL Estimation
- Chromosome: 2,3,4,7,9
- Location: NULL
- % Phenotypic Variation Accounted For: 76%
- Confidence Interval for QTL Estimation: NULL
- Comments:NULL
QTL Symbol: Unnamed
- QTL Detection Method: Correlation
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| Unnamed
| Ren-2
| 0.62
| NULL
| 1
|
| Unnamed
| D1Mit16
| 0.69
| NULL
| 1
|
| Unnamed
| D3Mit5
| -0.66
| NULL
| 3
|
| Unnamed
| Pmv-26
| -0.61
| NULL
| 3
|
| Unnamed
| Iapla2-14
| -0.55
| NULL
| 3
|
| Unnamed
| P40-4
| -0.55
| NULL
| 3
|
| Unnamed
| Sac
| -0.71
| NULL
| 4
|
| Unnamed
| D4Bir1
| -0.69
| NULL
| 4
|
| Unnamed
| Tel4q
| -0.66
| NULL
| 4
|
| Unnamed
| Iapls3-7
| -0.66
| NULL
| 18
|
| Unnamed
| D18Mit4
| -0.55
| NULL
| 18
|
| Unnamed
| Grl-1
| -0.60
| NULL
| 18
|
- QTL Estimation
- Chromosome: 1,3,4,18
- Location: NULL
- % Phenotypic Variation Accounted For: 69%
- Confidence Interval for QTL Estimation: NULL
- Comments:NULL
QTL Symbol: Unnamed
- QTL Detection Method: Correlation
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| Unnamed
| Ren-2
| 0.60
| NULL
| 1
|
| Unnamed
| D1Mit16
| 0.57
| NULL
| 1
|
| Unnamed
| D2Mc2
| -0.49
| NULL
| 2
|
| Unnamed
| D3Mit5
| -0.62
| NULL
| 3
|
| Unnamed
| Pmv-26
| -0.72
| NULL
| 3
|
| Unnamed
| Iapla2-14
| -0.59
| NULL
| 3
|
| Unnamed
| P40-4
| -0.59
| NULL
| 3
|
| Unnamed
| Sac
| -0.55
| NULL
| 4
|
| Unnamed
| D4Bir1
| -0.62
| NULL
| 4
|
| Unnamed
| Rasl4
| -0.47
| NULL
| 7
|
| Unnamed
| D15Mit3
| -0.65
| NULL
| 15
|
| Unnamed
| D18Mit4
| -0.61
| NULL
| 18
|
| Unnamed
| Grl-1
| -0.56
| NULL
| 18
|
- QTL Estimation
- Chromosome: 1,2,3,4,7,15,18
- Location: NULL
- % Phenotypic Variation Accounted For: 89%
- Confidence Interval for QTL Estimation: NULL
- Comments:NULL
QTL Symbol: Unnamed
- QTL Detection Method: Correlation
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| Unnamed
| D1Mit15
| 0.56
| NULL
| 1
|
| Unnamed
| Myif
| 0.67
| NULL
| 1
|
| Unnamed
| D1Byu1
| 0.62
| NULL
| 1
|
| Unnamed
| D3Mit5
| -0.54
| NULL
| 3
|
| Unnamed
| Sac
| -0.81
| NULL
| 4
|
| Unnamed
| D4Bir1
| -0.72
| NULL
| 4
|
| Unnamed
| Tel4q
| -0.66
| NULL
| 4
|
| Unnamed
| Xmmv-29
| 0.62
| NULL
| 8
|
| Unnamed
| D13Mit9
| -0.65
| NULL
| 13
|
| Unnamed
| Rasa
| -0.63
| NULL
| 13
|
| Unnamed
| As-1
| -0.64
| NULL
| 13
|
| Unnamed
| Lth-1
| -0.63
| NULL
| 13
|
| Unnamed
| D13Bir1
| -0.59
| NULL
| 13
|
| Unnamed
| D18Mit14
| -0.51
| NULL
| 18
|
| Unnamed
| Grl-1
| -0.59
| NULL
| 18
|
- QTL Estimation
- Chromosome: 1,3,4,8,13,18
- Location: NULL
- % Phenotypic Variation Accounted For: 78%
- Confidence Interval for QTL Estimation: NULL
- Comments:NULL
| QTL Symbol(s) |
Candidate Gene Symbol |
Chromosome |
Gene Name |
| Unnamed
| Drd2
| 7
| dopamine D2 receptor
|
- 1) ethanol acceptance/avidity and saccharin acceptance/avidity share
some genetic loci but also have distinct loci associated with these
traits.
- 2) there is some evidence for dependence on ethanol followed by
withdrawal of ethanol source as indicated by increased handling
induced convulsions (HICs). severity of convulsions was signifianctly
associated with dose of sweetened 10% ethanol solution consumed
just prior to withdrawal.
- 3) taken as a whole, the QTLs identified in the study appear to
account for 73% of the genetic variance in alcohol acceptance.
- 4) no significant correlation between saccharin consumption and
intake of unsweetened ethanol solutions.
Back to QTL Summary Table