Caution: These are Prototype Reports for Internal Evaluation Purposes Only!
MGD Full QTL Report
J# 15048 Bureau et al., 1993
Bibliographic information for J15048
Phenotype Information
Progeny Population Information
Methods
QTL Data
Candidate Genes
General Comments
- Phenotype Class: Resistance/Susceptibility
- Phenotype Mode: Induced
- Induced by: intracranial inoculation with 10^4 pfu of DA strain of TMEV
- Phenotype Name: Susceptibility to Theiler's Murine Encephalomyelitis Virus
- Phenotype Trait 1: Viral persistance
- Phenotype Assessment: semi-quantitative
- Alternative Keywords: MS, multiple sclerosis, demyelinating disease, central nervous system, TMEV
- Strain/Progenitor Information:
- Strain 1:SJL/J
- Strain 1 Comment: highly susceptible to TMEV persistent
infection
- Strain 2: B10.S
- Strain 2 Comment: resistant to TMEV persistent infection
- Phenotype Comments: 1) viral persistence measured as amount of viral RNA in spinal cord 45 days post inoculation
- Progeny Generation Used for QTL Experiment: N1
- Progeny Population Name: NULL
- # Animals Evaluated: 79
- Female Parent:(SJL/J X B10.S)F1
- Male Parent: B10.S
- Cross Type: backcross to male parent
- Another cross for this progeny population?: No
- Comments:
- (SJL/J X B10.S)F1 mice are as susceptible as SJL/J mice
- Chromosomes Evaluated:Autosomal only
- Marker Map Methods:
- Total Number of Markers in Analysis:89
- Intermarker Distance: from 2 cM to 42 cM
- Comments on Marker Map:
- 85 microsatellite markers and 4 RFLPs
- QTL Detection Method:
- unpaired Student's t test
- non-parametric Mann-Whitney
- Significance Threshold for QTL Detection: NULL
- Significance Threshold Comment:NULL
- QTL Estimation Method: NULL
- Comments on QTL Estimation Model Used: NULL
- QTL Mapping Software:NULL
- Other QTL Mapping Software: NULL
QTL Symbol: Unnamed
- QTL Detection Method: unpaired Student's t test
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| unnamed
| D10Mit14
| NULL
| =0.0002
| 10
|
| unnamed
| Ifg
| NULL
| =0.0002
| 10
|
| unnamed
| Mdm-1
| NULL
| =0.0002
| 10
|
- QTL Estimation:
- Chromosome: 10
- Location: telomeric region of chromosome 10
- % Phenotypic Variation Accounted For: 17.1%
- Confidence Interval for QTL Estimation: NULL
- Comments:
- 1) Authors estimate between 28-56% of genetic variation in Viral persistance accounted for by the putative QTL on chromosome 10.
QTL Data for J15048
QTL Symbol: Unnamed
- QTL Detection Method:Unpaired Student's t test
- Table of Linked Markers:
| QTL Symbol |
Linked Marker Symbol |
Association Score |
P Value |
Chromosome |
| Unnamed
| D18Mit8
| NULL
| =0.0067
| 18
|
| Unnamed
| D18Mit3
| NULL
| =0.0067
| 18
|
| Unnamed
| D18Mit4
| NULL
| =0.0020
| 18
|
| Unnamed
| Mbp
| NULL
| =0.0020
| 18
|
- QTL Estimation:
- Chromosome: 18
- Location: approximately 53 cM from the centromere
- % Phenotypic Variation Accounted For: 6.8%
- Confidence Interval for QTL Estimation: NULL
- Comments:NULL
| QTL Symbol(s) |
Candidate Gene Symbol |
Chromosome |
Gene Name |
| NULL
| Ifng
| 10
| interferon, gamma
|
| NULL
| Mbp
| 18
| myelin basic protein
|
1) Authors suggest that the persistence of TMEV in the central nervous system of mice is controlled by 2 or 3 loci.
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