Sequence Detail

ID/Version

Q06507 Q5U4B2 Q61906 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cyclic AMP-dependent transcription factor ATF-4 {ECO:0000305}; Short=cAMP-dependent transcription factor ATF-4 {ECO:0000305};AltName: Full=Activating transcription factor 4 {ECO:0000303|PubMed:11018027};AltName: Full=C/EBP-related AT

Provider

SWISS-PROT

Sequence

Polypeptide 349 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atf4	activating transcription factor 4	204	142	4	23

Sequence references in MGI

J:33282 Chevray PM, et al., Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5789-93
J:34756 Vallejo M, et al., C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4679-83
J:56007 Tanaka T, et al., Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Genes Cells. 1998 Dec;3(12):801-10
J:62578 Hettmann T, et al., Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol. 2000 Jun 1;222(1):110-23
J:74479 Masuoka HC, et al., Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood. 2002 Feb 1;99(3):736-45
J:85101 Chen A, et al., Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins. Neuron. 2003 Aug 14;39(4):655-69
J:89403 Yang X, et al., ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 2004 Apr 30;117(3):387-98
J:99455 Harding HP, et al., Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell. 2000 Nov;6(5):1099-108
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100180 Yu VW, et al., FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. J Cell Biol. 2005 May 23;169(4):591-601
J:115876 Dobreva G, et al., SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 2006 Jun 2;125(5):971-86
J:137331 Harding HP, et al., An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 2003 Mar;11(3):619-33
J:148804 Yu VW, et al., FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes. Gene Expr Patterns. 2009 Jun;9(5):335-40
J:159084 Podust LM, et al., Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA. J Biol Chem. 2001 Jan 5;276(1):505-13
J:167725 Galehdar Z, et al., Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. J Neurosci. 2010 Dec 15;30(50):16938-48
J:176743 Koyanagi S, et al., cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J Biol Chem. 2011 Sep 16;286(37):32416-23
J:183276 Kode A, et al., FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis. J Biol Chem. 2012 Mar 16;287(12):8757-68
J:189996 Ohoka N, et al., TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 2005 Mar 23;24(6):1243-55
J:193213 Ambivero CT, et al., ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway. Biochim Biophys Acta. 2012 Dec;1823(12):2149-56
J:198492 Han J, et al., ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol. 2013 May;15(5):481-90
J:198927 Csibi A, et al., The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2013 May 9;153(4):840-54
J:232292 Scortegagna M, et al., Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet. 2014 May;10(5):e1004348
J:244183 Ushijima K, et al., Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain. Mol Pharmacol. 2012 Aug;82(2):264-70
J:278383 Balsa E, et al., ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2alpha Axis. Mol Cell. 2019 Jun 6;74(5):877-890.e6