References
Query Results -- Details
MGI Accession ID: MGI:3815355
J Number: J:141084
Other Accession IDs:
Title: Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.
Authors: Sanchez-Mejia RO; Newman JW; Toh S; Yu GQ; Zhou Y; Halabisky B; Cisse M; Scearce-Levie K; Cheng IH; Gan L; Palop JJ; Bonventre JV; Mucke L
Journal: Nat Neurosci
Volume: 11
Issue: 11
Date: 2008 Nov
Year: 2008
Pages: 1311-8
Review Status: Peer Reviewed
Abstract:
Neuronal expression of familial Alzheimer's disease-mutant human amyloid precursor protein (hAPP) and hAPP-derived amyloid-beta (Abeta) peptides causes synaptic dysfunction, inflammation and abnormal cerebrovascular tone in transgenic mice. Fatty acids may be involved in these processes, but their contribution to Alzheimer's disease pathogenesis is uncertain. We used a lipidomics approach to generate a broad profile of fatty acids in brain tissues of hAPP-expressing mice and found an increase in arachidonic acid and its metabolites, suggesting increased activity of the group IV isoform of phospholipase A(2) (GIVA-PLA(2)). The levels of activated GIVA-PLA(2) in the hippocampus were increased in individuals with Alzheimer's disease and in hAPP mice. Abeta caused a dose-dependent increase in GIVA-PLA(2) phosphorylation in neuronal cultures. Inhibition of GIVA-PLA(2) diminished Abeta-induced neurotoxicity. Genetic ablation or reduction of GIVA-PLA(2) protected hAPP mice against Abeta-dependent deficits in learning and memory, behavioral alterations and premature mortality. Inhibition of GIVA-PLA(2) may be beneficial in the treatment and prevention of Alzheimer's disease.
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