References
Query Results -- Details
MGI Accession ID: MGI:3664733
J Number: J:113200
Other Accession IDs:
Title: Charaterization of amyloid deposition in the APPswe/PS2dE9 mouse model of Alzheimer disease
Authors: Garcia-Alloza M; Robbins EM; Zhang-Nunes SX; Prucell SM; Betensky RA; Raju S; Prada C; Greenberg SM; Bacskai BJ; Frosch MP
Journal: Neurobiol Dis
Volume: 24
Issue: 3
Date: 2006 Dec
Year: 2006
Pages: 516-524
Review Status: Peer Reviewed
Abstract:
Transgenic mice carrying disease-linked forms of genes associated with Alzheimer disease often demonstrate deposition of the beta-amyloid as senile plaques and cerebral amyloid angiopathy. We have characterized the natural history of beta-amyloid deposition in APPswe/PS1dE9 mice, a particularly aggressive transgenic mouse model generated with mutant transgenes for APP (APPswe: KM594/5NL) and PS1 (dE9: deletion of exon 9). Ex vivo histochemistry showed Abeta deposition by 4 months with a progressive increase in plaque number up to 12 months and a similar increase of Abeta levels. In vivo multiphoton microscopy at weekly intervals showed increasing beta-amyloid deposition as CAA and plaques. Although first appearing at an early age, CAA progressed at a significantly slower rate than in the Tg2576 mice. The consistent and early onset of beta-amyloid accumulation in the APPswe/PS1dE9 model confirms its utility for studies of biochemical and pathological mechanisms underlying beta-amyloid deposition, as well as exploring new therapeutic treatments.
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