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Clock Gene Detail
 Symbol
Name
ID
Clock
circadian locomoter output cycles kaput
MGI:99698


Nomenclature History
Synonyms 5330400M04Rik, bHLHe8, KAT13D, mKIAA0334
Genetic Map
Chromosome 5
43.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 21)

Sequence Map
Chr5:76641202-76733573 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Clock ± 2 cM)
TreeFam: TF324568
Sequences
Representative Sequences Length Strain/Species Flank
genomic 12753 NCBI Gene Model | MGI Sequence Detail 92372 C57BL/6J ± Kb
transcript NM_007715 RefSeq | MGI Sequence Detail 7478 C57BL/6
polypeptide O08785 UniProt | EBI | MGI Sequence Detail 855 Not Applicable
For the selected sequences
All sequences(32)
Alleles
and
phenotypes
All alleles(26) : Targeted, knock-out(1) Gene trapped(24) Chemically induced(1)
Mice homozygous for a knock-out allele exhibit abnormal circadian phase. Mice homozygous for a spontaneous mutation exhibit abnormal circadian rhythm, reproduction, behavior, hair cycle, macronutrient absorption, and metabolism.
Polymorphisms SNPs within 2kb(199 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(26)
Process circadian rhythm, positive regulation of transcription from RNA polymerase II promoter...
Component cytoplasm, nucleus...
Function acyltransferase activity, DNA binding...
External Resources: MouseFunc
Expression Literature Summary: (6 records)
Data Summary: Assays (5)    Results (155)    Tissues (140)    Images (14)
Theiler Stages: 1,2,3,4,5,17,21,22,28
  Assay Type Assays   Results
      RT-PCR 2   29
      RNA in situ 3   126
cDNA source data(21)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(34) Genomic(10) cDNA(21) Primer pair(3)
Microarray probesets(1)
Other database
links
NIA Mouse Gene Index U026318
Entrez Gene 12753
DoTS DT.101230942, DT.528388, DT.55142600, DT.99839908, DT.99839909
EC 2.3.1.48
Ensembl Gene Model ENSMUSG00000029238
International Mouse Knockout Project Status Clock
Protein
domains
InterPro ID Description
IPR000014 PAS
IPR001067 Nuclear translocator
IPR001092 Helix-loop-helix DNA-binding domain
IPR001610 PAC motif
IPR011598 Helix-loop-helix DNA-binding
IPR013655 PAS fold-3
IPR013767 PAS fold
Graphical View of Protein Domain Structure
References
(Earliest) J:18005 Vitaterna MH et al., "Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior." Science 1994 Apr 29;264(5159):719-25
(Latest) J:154095 Beaule C et al., "Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes." PLoS One 2009;4(10):e7476
All references(102)
Other
accession IDs
MGD-MRK-16483, MGI:2442107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory