Symbol
Name
ID
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Synonyms
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Srk, TZK, ZAP-70
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(22)
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Alleles
and
phenotypes
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All alleles(9) :
Targeted, knock-out(2)
Targeted, other(2)
Spontaneous(2)
Chemically induced(3)
| Mutant mice show T cell defects. Null mutants lack alpha-beta T cells in the thymus and have fewer T cells in dendritic and intestinal epithelium. Spontaneous and knock-in missense mutations affect T cell receptor signaling, one of the former resulting in severe chronic arthritis. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
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Polymorphisms
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RFLP(1)
SNPs within 2kb(58 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (1 records)
cDNA source data(18)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(20)
Genomic(1)
cDNA(19)
Microarray probesets(3)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR000980 |
SH2 motif |
| IPR001245 |
Tyrosine-protein kinase, catalytic domain |
| IPR008266 |
Tyrosine-protein kinase, active site |
| IPR012234 |
Tyrosine-protein kinase, non-receptor SYK/ZAP-70 |
| IPR017441 |
Protein kinase, ATP binding site |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:18037
Chan AC et al.,
"Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling."
J Immunol 1994 May 15;152(10):4758-66
(Latest)
J:154166
Hsu LY et al.,
"A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity."
J Exp Med 2009 Oct 26;206(11):2527-41
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All references(59)
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Other
accession IDs
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MGD-MRK-16398, MGI:2138217, MGI:3584397, MGI:3584398
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